DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-55 and MSI1

DIOPT Version :9

Sequence 1:	NP_524354.1	Gene:	Caf1-55 / 41836	FlyBaseID:	FBgn0263979	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_009754.1	Gene:	MSI1 / 852494	SGDID:	S000000399	Length:	422	Species:	Saccharomyces cerevisiae

Alignment Length:	437	Identity:	127/437 - (29%)
Similarity:	200/437 - (45%)	Gaps:	82/437 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 INEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDV-TKQDGKDYSVHRLILGTHTSDEQ---- 80
            :.|.|..|||||..|||.:.|::.:|||||.|:.||: |..|     .||::|.:.||.::
Yeast    19 LQERYSHWKKNTKLLYDYLNTNSTKWPSLTCQFFPDLDTTSD-----EHRILLSSFTSSQKPEDE 78

  Fly    81 ----------NHLLIASVQ---------LPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKIN 126
                      .|:..:|:.         .|....:|...|..|:...|  |.:
Yeast    79 TIYISKISTLGHIKWSSLNNFDMDEMEFKPENSTRFPSKHLVNDISIF--FPN------------ 129

  Fly   127 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPS-KPEPSGECQP-DLRLRGHQ-------- 181
              ||.|||||:|||..:||..:....:.:||.|||.| :...|....| :.:|.|..
Yeast   130 --GECNRARYLPQNPDIIAGASSDGAIYIFDRTKHGSTRIRQSKISHPFETKLFGSHGVIQDVEA 192

  Fly   182 --------KEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAK--NIFTGHTAVVED 236
                    .|...|:||......|||:..:..:.:|||.....|:.:||..  :|.:..|| |.|
Yeast   193 MDTSSADINEATSLAWNLQQEALLLSSHSNGQVQVWDIKQYSHENPIIDLPLVSINSDGTA-VND 256

  Fly   237 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKT 301
            |.|...|:|||.:..:...:.:.|.|.......|:. :.|...||...||..:..|||:..::..
Yeast   257 VTWMPTHDSLFAACTEGNAVSLLDLRTKKEKLQSNR-EKHDGGVNSCRFNYKNSLILASADSNGR 320

  Fly   302 VALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG-TDRRLHVWDLSKIGEEQSTEDAED 365
            :.|||:||:.....:...|...:..::|||:.:|:||::| .|..:.:||.|
Yeast   321 LNLWDIRNMNKSPIATMEHGTSVSTLEWSPNFDTVLATAGQEDGLVKLWDTS------------- 372

  Fly   366 GPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENV 412
             ..|.:|.||||...::|.||:.::||::|||:.||.:.:|:.|.|:
Yeast   373 -CEETIFTHGGHMLGVNDISWDAHDPWLMCSVANDNSVHIWKPAGNL 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-55	NP_524354.1	CAF1C_H4-bd	23..92	CDD:403473	28/92 (30%)
		WD40	127..408	CDD:421866	91/301 (30%)
		WD40 repeat	132..179	CDD:293791	19/48 (40%)
		WD40 repeat	184..228	CDD:293791	13/45 (29%)
		WD40 repeat	235..274	CDD:293791	10/38 (26%)
		WD40 repeat	280..318	CDD:293791	12/37 (32%)
		WD40 repeat	324..375	CDD:293791	13/51 (25%)
		WD40 repeat	381..406	CDD:293791	10/24 (42%)
MSI1	NP_009754.1	CAF1C_H4-bd	21..88	CDD:403473	26/71 (37%)
		WD40 repeat	133..173	CDD:293791	17/39 (44%)
		WD40	141..413	CDD:421866	81/287 (28%)
		WD40 repeat	203..247	CDD:293791	12/43 (28%)
		WD40 repeat	255..292	CDD:293791	10/36 (28%)
		WD40 repeat	299..338	CDD:293791	12/38 (32%)
		WD40 repeat	343..381	CDD:293791	13/51 (25%)
		WD40 repeat	387..412	CDD:293791	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0264
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53987
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101102
Panther	1	1.100	-	-	O	PTHR22850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.780