DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Caf1-55 and WDR73

DIOPT Version :9

Sequence 1:	NP_524354.1	Gene:	Caf1-55 / 41836	FlyBaseID:	FBgn0263979	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_116245.2	Gene:	WDR73 / 84942	HGNCID:	25928	Length:	378	Species:	Homo sapiens

Alignment Length:	392	Identity:	86/392 - (21%)
Similarity:	149/392 - (38%)	Gaps:	79/392 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 DEQNHLLIASVQLPSEDAQFDGS------HYDNEKGEF-GGFGSVCGKIEI-------------- 121
            |..:..|:.|::|..:...||.|      .:.::||.| .|:.|: .|.||
Human     2 DPGDDWLVESLRLYQDFYAFDLSGATRVLEWIDDKGVFVAGYESL-KKNEILHLKLPLRLSVKEN 65

  Fly   122 -------EIKINHEGEVNRA----RYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDL 175
                   :.|:.|.|..:|:    :::|....::.:..|...:.|:...      |.|...:...
Human    66 KGLFPERDFKVRHGGFSDRSIFDLKHVPHTRLLVTSGLPGCYLQVWQVA------EDSDVIKAVS 124

  Fly   176 RLRGHQKEGYGLSWNPNLNGY-LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED--- 236
            .:..|:||.   |..|.:..: .|:....|       .|..:..:|:|.::..|.:|:.|.|
Human   125 TIAVHEKEE---SLWPRVAVFSTLAPGVLH-------GARLRSLQVVDLESRKTTYTSDVSDSEE 179

  Fly   237 -VAWHLLHESLFGSVADDQKLMIWDTR------NNNTSKPSHTVDAHTAEVNCLSFNPYSEFILA 294
             .:..:|....|.......:|.:.|||      .|.:..|....:...|||......| ...|.:
Human   180 LSSLQVLDADTFAFCCASGRLGLVDTRQKWAPLENRSPGPGSGGERWCAEVGSWGQGP-GPSIAS 243

  Fly   295 TGSADKTVALWDLRNLKLKLHSFE------SHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSK 353
            .|| |..:.|.|.|:|...:.|.:      |...|:.:|.|:|..:..||.||.|..:.|:|.:.
Human   244 LGS-DGRLCLLDPRDLCHPVSSVQCPVSVPSPDPELLRVTWAPGLKNCLAISGFDGTVQVYDATS 307

  Fly   354 IGEEQSTEDAEDGPPELLFIHGGH----------TAKISDFSWNPNEPWIICSVSEDNIMQVWQM 408
            ....:| :|......|.||.|.||          ...::..:|:|..|..:.|.:.|..:.||..
Human   308 WDGTRS-QDGTRSQVEPLFTHRGHIFLDGNGMDPAPLVTTHTWHPCRPRTLLSATNDASLHVWDW 371

  Fly   409 AE 410
            .:
Human   372 VD 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-55	NP_524354.1	CAF1C_H4-bd	23..92	CDD:403473	4/13 (31%)
		WD40	127..408	CDD:421866	70/311 (23%)
		WD40 repeat	132..179	CDD:293791	6/50 (12%)
		WD40 repeat	184..228	CDD:293791	7/44 (16%)
		WD40 repeat	235..274	CDD:293791	9/48 (19%)
		WD40 repeat	280..318	CDD:293791	11/37 (30%)
		WD40 repeat	324..375	CDD:293791	15/50 (30%)
		WD40 repeat	381..406	CDD:293791	5/24 (21%)
WDR73	NP_116245.2	WD 1	73..113		7/39 (18%)
		WD40	<85..>304	CDD:225201	51/236 (22%)
		WD 2	121..163		9/51 (18%)
		WD 3	167..205		7/37 (19%)
		WD 4	214..255		11/42 (26%)
		WD40	<238..>370	CDD:225201	35/133 (26%)
		WD 5	266..305		11/38 (29%)
		WD40 repeat	279..329	CDD:293791	16/50 (32%)
		WD 6	322..371		13/48 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0264
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810