DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-55 and Rbbp7

DIOPT Version :9

Sequence 1:	NP_524354.1	Gene:	Caf1-55 / 41836	FlyBaseID:	FBgn0263979	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_114004.1	Gene:	Rbbp7 / 83712	RGDID:	620125	Length:	425	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	360/417 - (86%)
Similarity:	392/417 - (94%)	Gaps:	0/417 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGT 74
            |.|:|.|||||||||||||||||||||||||||||:|||||.||||:|||.:||||::|.|:|||
  Rat     5 EMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDYALHWLVLGT 69

  Fly    75 HTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQ 139
            |||||||||::|.|.:|::|||||.||.|::||||||||||.||||.||||||||||||||||||
  Rat    70 HTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQ 134

  Fly   140 NACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDH 204
            |..:|||||||||||||||||||:||:|||||.||||||||||||||||||.||:|:||||||||
  Rat   135 NPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDH 199

  Fly   205 TICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKP 269
            |:|||||||.|||.:::|||.|||||:|||||||||||||||||||||||||||||||:|.||||
  Rat   200 TVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKP 264

  Fly   270 SHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNE 334
            ||.|||||||||||||||||||||||||||||||||||||||||||:|||||||||||.||||||
  Rat   265 SHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNE 329

  Fly   335 TILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSE 399
            ||||||||||||:||||||||||||.||||||||||||||||||||||||||||||||:||||||
  Rat   330 TILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 394

  Fly   400 DNIMQVWQMAENVYNDEEPEIPASELE 426
            |||||:||||||:|||||.::..||||
  Rat   395 DNIMQIWQMAENIYNDEESDVTTSELE 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-55	NP_524354.1	CAF1C_H4-bd	23..92	CDD:403473	54/68 (79%)
		WD40	127..408	CDD:421866	254/280 (91%)
		WD40 repeat	132..179	CDD:293791	40/46 (87%)
		WD40 repeat	184..228	CDD:293791	33/43 (77%)
		WD40 repeat	235..274	CDD:293791	35/38 (92%)
		WD40 repeat	280..318	CDD:293791	36/37 (97%)
		WD40 repeat	324..375	CDD:293791	47/50 (94%)
		WD40 repeat	381..406	CDD:293791	23/24 (96%)
Rbbp7	NP_114004.1	CAF1C_H4-bd	18..87	CDD:403473	54/68 (79%)
		WD 1	47..122		54/74 (73%)
		WD40	122..402	CDD:421866	253/279 (91%)
		WD40 repeat	127..174	CDD:293791	40/46 (87%)
		WD 2	128..173		38/44 (86%)
		WD40 repeat	179..223	CDD:293791	33/43 (77%)
		WD 3	181..217		27/35 (77%)
		WD 4	228..269		37/40 (93%)
		WD40 repeat	230..264	CDD:293791	31/33 (94%)
		WD40 repeat	275..313	CDD:293791	36/37 (97%)
		WD 5	275..312		36/36 (100%)
		WD 6	318..369		47/50 (94%)
		WD40 repeat	319..370	CDD:293791	47/50 (94%)
		WD 7	376..403		24/26 (92%)
		WD40 repeat	376..401	CDD:293791	23/24 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342172
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0264
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53987
OrthoDB	1	1.010	-	-		D250544at33208
OrthoFinder	1	1.000	-	-		FOG0001098
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101102
Panther	1	1.100	-	-	O	PTHR22850
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X748
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.720