DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-55 and MSI1

DIOPT Version :9

Sequence 1:	NP_524354.1	Gene:	Caf1-55 / 41836	FlyBaseID:	FBgn0263979	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_200631.1	Gene:	MSI1 / 835935	AraportID:	AT5G58230	Length:	424	Species:	Arabidopsis thaliana

Alignment Length:	416	Identity:	271/416 - (65%)
Similarity:	332/416 - (79%)	Gaps:	3/416 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGT 74
            |.....:|||:|||||||||||||||||||:||||||||||.:||||..:..||||||.::||||
plant     6 EEMRGEIEERLINEEYKIWKKNTPFLYDLVITHALEWPSLTVEWLPDREEPSGKDYSVQKMILGT 70

  Fly    75 HTSD-EQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMP 138
            |||: |.|:|::|.||||.:|.:.:...||:::.||||||...||::|..:|||:||||||||||
plant    71 HTSESEPNYLMLAQVQLPLDDTESEARQYDDDRSEFGGFGCATGKVQIIQQINHDGEVNRARYMP 135

  Fly   139 QNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDD 203
            ||..:|||||.:::|.||||:||||||...|.|.|||:||||..|||||||:....|:|||.|||
plant   136 QNPFIIATKTVNAEVYVFDYSKHPSKPPLDGACNPDLKLRGHSSEGYGLSWSKFKQGHLLSGSDD 200

  Fly   204 HTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSK 268
            ..||||||||||| ::.:||:.||..|..|||||||||.||.|||||.|||.|:|||.|:.:.||
plant   201 AQICLWDINATPK-NKSLDAQQIFKAHEGVVEDVAWHLRHEYLFGSVGDDQYLLIWDLRSPSASK 264

  Fly   269 PSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN 333
            |..:|.||:.|||||:|||::|:::||||.||||.|:|||.|...||:|:|||:|:|||.|:|.|
plant   265 PVQSVVAHSMEVNCLAFNPFNEWVVATGSTDKTVKLFDLRKLSTALHTFDSHKEEVFQVGWNPKN 329

  Fly   334 ETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVS 398
            ||||||....|||.|||||:|.|||:.||||||||||||||||||:|||||||||.|.|:|.||:
plant   330 ETILASCCLGRRLMVWDLSRIDEEQTVEDAEDGPPELLFIHGGHTSKISDFSWNPCEDWVISSVA 394

  Fly   399 EDNIMQVWQMAENVYNDEEPEIPASE 424
            ||||:|:||||||:|:||: :.|..|
plant   395 EDNILQIWQMAENIYHDED-DAPGEE 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-55	NP_524354.1	CAF1C_H4-bd	23..92	CDD:403473	51/69 (74%)
		WD40	127..408	CDD:421866	189/280 (68%)
		WD40 repeat	132..179	CDD:293791	31/46 (67%)
		WD40 repeat	184..228	CDD:293791	27/43 (63%)
		WD40 repeat	235..274	CDD:293791	25/38 (66%)
		WD40 repeat	280..318	CDD:293791	23/37 (62%)
		WD40 repeat	324..375	CDD:293791	37/50 (74%)
		WD40 repeat	381..406	CDD:293791	18/24 (75%)
MSI1	NP_200631.1	CAF1C_H4-bd	19..88	CDD:403473	50/68 (74%)
		WD40	124..404	CDD:421866	189/280 (68%)
		WD40 repeat	129..176	CDD:293791	31/46 (67%)
		WD40 repeat	181..224	CDD:293791	27/43 (63%)
		WD40 repeat	231..270	CDD:293791	25/38 (66%)
		WD40 repeat	276..314	CDD:293791	23/37 (62%)
		WD40 repeat	320..371	CDD:293791	37/50 (74%)
		WD40 repeat	377..402	CDD:293791	18/24 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	114	1.000	Domainoid score	I2004
eggNOG	1	0.900	-	-		E1_KOG0264
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21153
Inparanoid	1	1.050	574	1.000	Inparanoid score	I238
OMA	1	1.010	-	-		QHG53987
OrthoDB	1	1.010	-	-		D831322at2759
OrthoFinder	1	1.000	-	-		FOG0001098
OrthoInspector	1	1.000	-	-		oto4067
orthoMCL	1	0.900	-	-		OOG6_101102
Panther	1	1.100	-	-	O	PTHR22850
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X748
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840