DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-55 and MSI2

DIOPT Version :9

Sequence 1:	NP_524354.1	Gene:	Caf1-55 / 41836	FlyBaseID:	FBgn0263979	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_179269.1	Gene:	MSI2 / 816179	AraportID:	AT2G16780	Length:	415	Species:	Arabidopsis thaliana

Alignment Length:	415	Identity:	221/415 - (53%)
Similarity:	291/415 - (70%)	Gaps:	25/415 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DDAVEER---VINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKD--YSVHRLIL 72
            |:..||.   .:.|::.:|||||||||||:::|.|||||||..|:|........|  :.||:|||
plant     3 DEGKEETGMGQVEEDFSVWKKNTPFLYDLLISHPLEWPSLTVHWVPSTPNPYVADSYFGVHKLIL 67

  Fly    73 GTHTS-DEQNHLLIASVQLPSEDAQ--FDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRA 134
            ||||| ..|:.|::|.|..|:.:|:  ..|::.|          ....|:||..:|..:||||||
plant    68 GTHTSGSAQDFLMVADVVTPTPNAEPGIGGANQD----------PFIPKVEIRQRIRVDGEVNRA 122

  Fly   135 RYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLS 199
            |.|||...::..||...:|.:|||.||.:|.:.| ||.|||||.||.||||||||:|...|||||
plant   123 RCMPQKPTLVGAKTSGCEVFLFDYAKHAAKSQTS-ECDPDLRLVGHDKEGYGLSWSPFKEGYLLS 186

  Fly   200 ASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNN 264
            .|.|..|||||::|||:: :|::|..::.||.:.:.||:||:.:|:||||..:|.:|:|||||
plant   187 GSQDQKICLWDVSATPQD-KVLNAMFVYEGHESAIADVSWHMKNENLFGSAGEDGRLVIWDTR-- 248

  Fly   265 NTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQW 329
             |::..|.|..|..|||.|||||::|::|||.|:|.||||:|||.|...||...||:.|:|||:|
plant   249 -TNQMQHQVKVHEREVNYLSFNPFNEWVLATASSDSTVALFDLRKLNAPLHVMSSHEGEVFQVEW 312

  Fly   330 SPHNETILASSGTDRRLHVWDLSKIGEEQ-STE-DAEDGPPELLFIHGGHTAKISDFSWNPNEPW 392
            .|::||:|||||.||||.||||:::|||| ..| |||||||||||.||||.||||||:||.||||
plant   313 DPNHETVLASSGEDRRLMVWDLNRVGEEQLEIELDAEDGPPELLFSHGGHKAKISDFAWNKNEPW 377

  Fly   393 IICSVSEDNIMQVWQMAENVYNDEE 417
            :|.||:|||.:|||||||::|.|||
plant   378 VIASVAEDNSLQVWQMAESIYRDEE 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-55	NP_524354.1	CAF1C_H4-bd	23..92	CDD:403473	37/71 (52%)
		WD40	127..408	CDD:421866	165/282 (59%)
		WD40 repeat	132..179	CDD:293791	24/46 (52%)
		WD40 repeat	184..228	CDD:293791	24/43 (56%)
		WD40 repeat	235..274	CDD:293791	18/38 (47%)
		WD40 repeat	280..318	CDD:293791	23/37 (62%)
		WD40 repeat	324..375	CDD:293791	36/52 (69%)
		WD40 repeat	381..406	CDD:293791	17/24 (71%)
MSI2	NP_179269.1	CAF1C_H4-bd	16..88	CDD:403473	37/71 (52%)
		WD40 repeat	120..166	CDD:293791	24/46 (52%)
		WD40	<164..>397	CDD:225201	143/236 (61%)
		WD40 repeat	171..208	CDD:293791	23/37 (62%)
		WD40 repeat	221..257	CDD:293791	18/38 (47%)
		WD40 repeat	263..301	CDD:293791	23/37 (62%)
		WD40 repeat	307..360	CDD:293791	36/52 (69%)
		WD40 repeat	366..391	CDD:293791	17/24 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	111	1.000	Domainoid score	I2076
eggNOG	1	0.900	-	-		E1_KOG0264
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53987
OrthoDB	1	1.010	-	-		D831322at2759
OrthoFinder	1	1.000	-	-		FOG0001098
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22850
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X748
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.890