DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-55 and Wdr73

DIOPT Version :9

Sequence 1:	NP_524354.1	Gene:	Caf1-55 / 41836	FlyBaseID:	FBgn0263979	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_082302.2	Gene:	Wdr73 / 71968	MGIID:	1919218	Length:	371	Species:	Mus musculus

Alignment Length:	402	Identity:	86/402 - (21%)
Similarity:	145/402 - (36%)	Gaps:	117/402 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 LIASVQLPSEDAQFDGS------HYDNEKGEF-GGFGSVCGKIEI-------------------- 121
            |:.|::|..:...||.|      .:..|||.| .|:.|: .|.||
Mouse     8 LVESLRLYQDFHAFDLSGATRVLEWIGEKGVFVAGYESL-KKNEILHLILPLRLSVQENQGLHPE 71

  Fly   122 -EIKINHEGEVNRA----RYMPQNACVIATKTP-----------SSDVLVFDYT-----KHPSK- 164
             :.|:.|.|..:|:    :::|....::.:..|           .:||:....|     |..|.
Mouse    72 RDFKVRHGGFSDRSVFDLKHVPDTRLLVTSGLPGCYIQMWQVREDNDVIEAVSTIDVQDKEESLW 136

  Fly   165 PEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDA---KNI 226
            |..|..|          .:..|:.....|:|.                      |.:|.   |..
Mouse   137 PRVSVFC----------SKAPGILHGARLSGL----------------------RTVDVESQKIT 169

  Fly   227 FTGHTAVVEDVA-WHLLHESLFGSVADDQKLMIWDTRNN----NTSKPSH--TVDAHTAEVNCLS 284
            ::..||..|.:: ..:|..:.|....:..:|.:.|||..    .|..|..  :.:...|||....
Mouse   170 YSSGTADSESLSCLQVLDANTFAFCGNSGRLGLVDTRQKWAALETVSPGSGCSGERWCAEVRNKG 234

  Fly   285 FNPYSEFILATGSADKTVALWDLRNLKLKLHS-----FESHKD-EIFQVQWSPHNETILASSGTD 343
            ..| ...|.:.|| |..:.|.|.|||...:.|     |:...| |:.:|.|:|..:..||.||.|
Mouse   235 QGP-GPCIASLGS-DGQLCLLDSRNLCHPVSSAQCPVFKPSPDPELLRVTWAPGLDNCLAISGFD 297

  Fly   344 RRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGH----------TAKISDFSWNPNEPWIICSVS 398
            ..:.::|:       ::.|.:....|.||.|.||          ...::..:|:|.:|..:.|.:
Mouse   298 GTVQIYDV-------TSWDGKKTQAEPLFTHKGHIFLDGNDVDSAPLVTTHTWHPRKPRTLLSAA 355

  Fly   399 EDNIMQVWQMAE 410
            .|:.:.||...:
Mouse   356 SDSSLHVWDWVD 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-55	NP_524354.1	CAF1C_H4-bd	23..92	CDD:403473	3/7 (43%)
		WD40	127..408	CDD:421866	70/327 (21%)
		WD40 repeat	132..179	CDD:293791	11/67 (16%)
		WD40 repeat	184..228	CDD:293791	6/46 (13%)
		WD40 repeat	235..274	CDD:293791	9/45 (20%)
		WD40 repeat	280..318	CDD:293791	12/42 (29%)
		WD40 repeat	324..375	CDD:293791	13/50 (26%)
		WD40 repeat	381..406	CDD:293791	5/24 (21%)
Wdr73	NP_082302.2	WD 1	81..121		5/39 (13%)
		WD40	<238..>364	CDD:295369	35/133 (26%)
		WD40	<238..>364	CDD:225201	35/133 (26%)
		WD 2	273..313		12/46 (26%)
		WD40 repeat	279..322	CDD:293791	13/49 (27%)
		WD 3	333..371		7/35 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0264
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810