DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-55 and RBBP7

DIOPT Version :9

Sequence 1:	NP_524354.1	Gene:	Caf1-55 / 41836	FlyBaseID:	FBgn0263979	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001185648.1	Gene:	RBBP7 / 5931	HGNCID:	9890	Length:	469	Species:	Homo sapiens

Alignment Length:	415	Identity:	359/415 - (86%)
Similarity:	391/415 - (94%)	Gaps:	0/415 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGTHT 76
            |:|.|||||||||||||||||||||||||||||:|||||.||||:|||.:||||::|.|:|||||
Human    51 FEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDYALHWLVLGTHT 115

  Fly    77 SDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNA 141
            |||||||::|.|.:|::|||||.||.|::||||||||||.||||.|||||||||||||||||||.
Human   116 SDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQNP 180

  Fly   142 CVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTI 206
            .:|||||||||||||||||||:||:|||||.||||||||||||||||||.||:|:|||||||||:
Human   181 HIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTV 245

  Fly   207 CLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSH 271
            |||||||.|||.:::|||.|||||:|||||||||||||||||||||||||||||||:|.||||||
Human   246 CLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSH 310

  Fly   272 TVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETI 336
            .|||||||||||||||||||||||||||||||||||||||||||:|||||||||||.||||||||
Human   311 LVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETI 375

  Fly   337 LASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDN 401
            ||||||||||:||||||||||||.||||||||||||||||||||||||||||||||:||||||||
Human   376 LASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDN 440

  Fly   402 IMQVWQMAENVYNDEEPEIPASELE 426
            |||:||||||:|||||.::..||||
Human   441 IMQIWQMAENIYNDEESDVTTSELE 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-55	NP_524354.1	CAF1C_H4-bd	23..92	CDD:403473	54/68 (79%)
		WD40	127..408	CDD:421866	254/280 (91%)
		WD40 repeat	132..179	CDD:293791	40/46 (87%)
		WD40 repeat	184..228	CDD:293791	33/43 (77%)
		WD40 repeat	235..274	CDD:293791	35/38 (92%)
		WD40 repeat	280..318	CDD:293791	36/37 (97%)
		WD40 repeat	324..375	CDD:293791	47/50 (94%)
		WD40 repeat	381..406	CDD:293791	23/24 (96%)
RBBP7	NP_001185648.1	CAF1C_H4-bd	62..131	CDD:372002	54/68 (79%)
		WD40	166..446	CDD:392136	253/279 (91%)
		WD40 repeat	171..218	CDD:293791	40/46 (87%)
		WD40 repeat	223..267	CDD:293791	33/43 (77%)
		WD40 repeat	274..308	CDD:293791	31/33 (94%)
		WD40 repeat	319..357	CDD:293791	36/37 (97%)
		WD40 repeat	363..414	CDD:293791	47/50 (94%)
		WD40 repeat	420..445	CDD:293791	23/24 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148299
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0264
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S514
OMA	1	1.010	-	-		QHG53987
OrthoDB	1	1.010	-	-		D250544at33208
OrthoFinder	1	1.000	-	-		FOG0001098
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101102
Panther	1	1.100	-	-	O	PTHR22850
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R552
SonicParanoid	1	1.000	-	-		X748
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.700