DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-55 and wdr73

DIOPT Version :9

Sequence 1:	NP_524354.1	Gene:	Caf1-55 / 41836	FlyBaseID:	FBgn0263979	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_031752175.1	Gene:	wdr73 / 496983	XenbaseID:	XB-GENE-5809223	Length:	378	Species:	Xenopus tropicalis

Alignment Length:	442	Identity:	86/442 - (19%)
Similarity:	162/442 - (36%)	Gaps:	128/442 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 NEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGTHTSDEQNHLLIA 86
            :|||:.|...:..||..:....|:.|:...:|:.|.:           :.:..:...::|.:|
Frog     3 SEEYEEWLVESIRLYKDLHDFELQDPTRVVEWIGDKS-----------ICVAGYDGTKRNEIL-- 54

  Fly    87 SVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGEVNR----ARYMPQNACVIATK 147
            .:.:|.:      .|.....|       :|.  |.::|:.|.|.::.    .:::||:: :|.|.
Frog    55 QLLIPQK------LHAKENPG-------LCP--ERDLKVEHGGFIDEPVYSLKHIPQSS-LIVTS 103

  Fly   148 TPSS-------------DVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSW-----NPNLN 194
            .|:.             ||:|      |....|:.        .|::      :|     .|:..
Frog   104 GPTGCPLRVWQIGPEDRDVIV------PLSTLPTD--------AGNE------TWTRTATTPSAP 148

  Fly   195 GYLLSASDDHTICLWDINATPKEHRVIDAKNIFT----GHTAVVEDVAWHLLHESLFGSVADDQK 255
            ..:|..|..::|.|.:|.:|         |.|:|    |..|:  .....|...::|....:.::
Frog   149 PQILHGSQANSIHLTEIQST---------KRIYTLGLSGSDAL--STLGFLDPYTVFVCCRNGRQ 202

  Fly   256 LMIWDTRNNNTSKPSHTVDAH--TAEVNCLSFNPYSEFILATGSADKTVA---------LWDLRN 309
            .|. |.|....:... :|..|  ::...|.:.||      :.|:|..|||         |.|.||
Frog   203 CMA-DVRMPGAACEG-SVGKHGLSSAAWCAAVNP------SKGAACSTVASLSAEGHVCLTDARN 259

  Fly   310 LKLKLHSFE------SHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPP 368
            |...|...:      :..:....|.|:|.....::.||....:.::|..:       .|......
Frog   260 LSAPLKCAKCRVPKPAAPEHFLNVCWAPALSDCISLSGFGGTVQIFDTKQ-------WDCAMKER 317

  Fly   369 ELLFIHGGHTAK----------ISDFSWNPNEPWIICSVSEDNIMQVWQMAE 410
            |.||||.||:..          ::..||:|.:...:.|.:.|..:.||..::
Frog   318 EALFIHRGHSVMGASEAGSEPIVTAHSWHPWKERTVLSAASDGSLHVWNWSD 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-55	NP_524354.1	CAF1C_H4-bd	23..92	CDD:403473	12/68 (18%)
		WD40	127..408	CDD:421866	68/333 (20%)
		WD40 repeat	132..179	CDD:293791	10/63 (16%)
		WD40 repeat	184..228	CDD:293791	10/48 (21%)
		WD40 repeat	235..274	CDD:293791	5/38 (13%)
		WD40 repeat	280..318	CDD:293791	14/46 (30%)
		WD40 repeat	324..375	CDD:293791	11/50 (22%)
		WD40 repeat	381..406	CDD:293791	5/24 (21%)
wdr73	XP_031752175.1	WD40	<85..370	CDD:225201	66/332 (20%)
		WD40 repeat	88..131	CDD:293791	9/49 (18%)
		WD40 repeat	140..176	CDD:293791	10/44 (23%)
		WD40 repeat	181..218	CDD:293791	6/40 (15%)
		WD40 repeat	228..274	CDD:293791	14/51 (27%)
		WD40 repeat	281..324	CDD:293791	11/49 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910