DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-55 and rbbp4

DIOPT Version :9

Sequence 1:	NP_524354.1	Gene:	Caf1-55 / 41836	FlyBaseID:	FBgn0263979	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_017946704.1	Gene:	rbbp4 / 496866	XenbaseID:	XB-GENE-482002	Length:	426	Species:	Xenopus tropicalis

Alignment Length:	420	Identity:	378/420 - (90%)
Similarity:	401/420 - (95%)	Gaps:	5/420 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVDRSDNAAESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDY 65
            |.|:.    .:|||||||||||||||||||||||||||||||||||||||||||||||:.||||:
Frog     1 MADKE----AAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPDGKDF 61

  Fly    66 SVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGE 130
            |:|||:||||||||||||:|||||||::|||||.||||:|||||||||||.||||||||||||||
Frog    62 SIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGE 126

  Fly   131 VNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNG 195
            ||||||||||.|:||||||||||||||||||||||:|||||.|||||||||||||||||||||:|
Frog   127 VNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSG 191

  Fly   196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWD 260
            .|||||||||||||||:|.|||.:|:|||.||||||||||||:||||||||||||||||||||||
Frog   192 NLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWD 256

  Fly   261 TRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIF 325
            ||:||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   257 TRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIF 321

  Fly   326 -QVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPN 389
             |||||||||||||||||||||:||||||||||||.|||||||||||||||||||||||||||||
Frog   322 QQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPN 386

  Fly   390 EPWIICSVSEDNIMQVWQMAENVYNDEEPE 419
            |||:||||||||||||||||||:||||:.|
Frog   387 EPWVICSVSEDNIMQVWQMAENIYNDEDTE 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-55	NP_524354.1	CAF1C_H4-bd	23..92	CDD:403473	62/68 (91%)
		WD40	127..408	CDD:421866	262/281 (93%)
		WD40 repeat	132..179	CDD:293791	42/46 (91%)
		WD40 repeat	184..228	CDD:293791	35/43 (81%)
		WD40 repeat	235..274	CDD:293791	35/38 (92%)
		WD40 repeat	280..318	CDD:293791	37/37 (100%)
		WD40 repeat	324..375	CDD:293791	48/51 (94%)
		WD40 repeat	381..406	CDD:293791	23/24 (96%)
rbbp4	XP_017946704.1	CAF1C_H4-bd	19..88	CDD:372002	62/68 (91%)
		WD40	122..404	CDD:392136	262/281 (93%)
		WD40 repeat	128..175	CDD:293791	42/46 (91%)
		WD40 repeat	180..224	CDD:293791	35/43 (81%)
		WD40 repeat	231..270	CDD:293791	35/38 (92%)
		WD40 repeat	276..314	CDD:293791	37/37 (100%)
		WD40 repeat	322..372	CDD:293791	46/49 (94%)
		WD40 repeat	378..403	CDD:293791	23/24 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	167	1.000	Domainoid score	I3799
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21153
Inparanoid	1	1.050	806	1.000	Inparanoid score	I482
OMA	1	1.010	-	-		QHG53987
OrthoDB	1	1.010	-	-		D250544at33208
OrthoFinder	1	1.000	-	-		FOG0001098
OrthoInspector	1	1.000	-	-		otm48749
Panther	1	1.100	-	-	LDO	PTHR22850
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R552
SonicParanoid	1	1.000	-	-		X748
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110