DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-55 and Wdr59

DIOPT Version :9

Sequence 1:	NP_524354.1	Gene:	Caf1-55 / 41836	FlyBaseID:	FBgn0263979	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_609485.4	Gene:	Wdr59 / 34540	FlyBaseID:	FBgn0032339	Length:	969	Species:	Drosophila melanogaster

Alignment Length:	410	Identity:	100/410 - (24%)
Similarity:	163/410 - (39%)	Gaps:	116/410 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 VTKQDGKDYSVHRLILGTHTSDE----------QNHLLIASVQLPSEDAQFDG--------SHYD 103
            :.:|..|.|. ||....|..|.:          :.||.:..:      .|.||        |.|:
  Fly    28 IVRQSNKYYE-HRDSQATAMSVDYSGQWVLLAGRGHLALQRL------GQDDGSLRRHERQSKYE 85

  Fly   104 NEKGEFGGFGSVCGKIEIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPS 168
            ....||    ::|              .:|..|     |.||| :...|::.:
  Fly    86 VSVAEF----AIC--------------PSRKEY-----CAIAT-SQHIDIVRW------------ 114

  Fly   169 GECQP--DLRLRGHQKEGYGLSW---NPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFT 228
            |..:|  ::.||||.:....:.|   :|||   |:|.|.|....:||:....|....::|. ..:
  Fly   115 GTAEPHYEMSLRGHTRTVTDIDWHGKDPNL---LVSCSIDTFSHIWDLREPRKPALSLNAV-CMS 175

  Fly   229 GHTAV-VEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFI 292
            |.|.| ...|:.:||      :.|.|..|.|||.|..  |.|:|.:.||...|:.::::...|..
  Fly   176 GATQVGFNRVSGNLL------AAAHDGDLRIWDIRKG--SCPTHYITAHLNRVHGINWSHKRETC 232

  Fly   293 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA------SSGTDRRLHVWDL 351
            |||.|.|.||..:|:.|.: :.....:....:::.:::|....:::      ..| :..|.:|..
  Fly   233 LATASQDGTVKYFDVCNPR-RAEKIITTMSPVWRARYTPIGNGLVSIVVPHLGRG-ENSLLLWSN 295

  Fly   352 SKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE---------PWIICSVSEDNIMQVWQ 407
            ||     .|:      |...|:  |||..|.||:|.||.         .|     |.|..::||:
  Fly   296 SK-----QTD------PICSFV--GHTDVILDFAWRPNRESSNEIELVTW-----SRDRTLRVWK 342

  Fly   408 MAENVYNDEEPEIPASELET 427
            :.:|:....||.  |.|:|:
  Fly   343 IDDNMLKLCEPS--AEEIES 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-55	NP_524354.1	CAF1C_H4-bd	23..92	CDD:403473	9/44 (20%)
		WD40	127..408	CDD:421866	77/301 (26%)
		WD40 repeat	132..179	CDD:293791	10/48 (21%)
		WD40 repeat	184..228	CDD:293791	12/46 (26%)
		WD40 repeat	235..274	CDD:293791	13/38 (34%)
		WD40 repeat	280..318	CDD:293791	11/37 (30%)
		WD40 repeat	324..375	CDD:293791	9/56 (16%)
		WD40 repeat	381..406	CDD:293791	9/33 (27%)
Wdr59	NP_609485.4	WD40	<92..343	CDD:225201	78/314 (25%)
		WD40 repeat	132..170	CDD:293791	11/40 (28%)
		WD40 repeat	178..213	CDD:293791	15/42 (36%)
		WD40 repeat	220..259	CDD:293791	11/39 (28%)
		WD40 repeat	263..306	CDD:293791	8/54 (15%)
		WD40 repeat	312..341	CDD:293791	9/33 (27%)
		mRING-H2-C3H3C2_WDR59	912..957	CDD:319606
		modified RING-H2 finger (C3H3C2-type)	914..953	CDD:319606
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456800
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840