DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-55 and Grwd1

DIOPT Version :9

Sequence 1:	NP_524354.1	Gene:	Caf1-55 / 41836	FlyBaseID:	FBgn0263979	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001012067.1	Gene:	Grwd1 / 308592	RGDID:	1310649	Length:	445	Species:	Rattus norvegicus

Alignment Length:	431	Identity:	114/431 - (26%)
Similarity:	181/431 - (41%)	Gaps:	91/431 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EERVINEE-YKIWKK---NTPFL-YDLVMTH----ALEWPSLTAQWLPDVTKQDGKDYSVHRLIL 72
            ||.|::|| |.::.:   ..|.| :|:|..|    ..|.|                 .|:: |..
  Rat    45 EELVMDEEAYVLYHRAQTGAPCLSFDIVRDHLGDNRTELP-----------------LSLY-LCA 91

  Fly    73 GTHTSDEQN--------HLLIASVQLPSE--DAQFDGSHYDNEKGEFGGFGSVCGKIEIEI-KIN 126
            ||.....|:        |.|..:...|||  |.:.|....|.|:          .|.::|: .:.
  Rat    92 GTQAESAQSNRLMMLRMHNLHGTRPPPSEGSDDEDDEDEEDEEE----------RKPQLELAMVP 146

  Fly   127 HEGEVNRAR--YMPQNACVIATKTPSSDVLVF------DYTKHPSK-----PEPSGECQPDLRLR 178
            |.|.:||.|  ::.:.. |....:....|.||      .....|..     .:.....:|.....
  Rat   147 HYGGINRVRVSWLGEEP-VAGVWSEKGQVEVFALRRLLQVVDDPQALAIFLRDEQARVKPIFSFA 210

  Fly   179 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNI----FTGHTAVVEDVAW 239
            ||..||:.|.|:|.:.|.||:......|.||    ||.:.   .:.|:    |.|||..|||:.|
  Rat   211 GHMGEGFALDWSPRVPGRLLTGDCQKNIHLW----TPTDG---GSWNVDQRPFVGHTRSVEDLQW 268

  Fly   240 HLLHESLFGSVADDQKLMIWDTRNNNTSKPSH-----TVDAHTAEVNCLSFNPYSEFILATGSAD 299
            ....:::|.|.:.|..:.|||.|    :.|..     |..||..:||.:|::....|:| :|..|
  Rat   269 SPTEDTVFASCSADASIRIWDIR----AAPGKACMLTTAAAHDGDVNVISWSRREPFLL-SGGDD 328

  Fly   300 KTVALWDLRNLK--LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTED 362
            .|:.:||||..|  ..:.:|:.|...:..|:|.|.:..:.|:||.|.::..|||:...:.:|.|.
  Rat   329 GTLKVWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADNQITQWDLAVERDPESGET 393

  Fly   363 AEDG-----PPELLFIHGGHTAKISDFSWNPNEPWIICSVS 398
            ..|.     |.:|||:|.|.| .:.:..|:|..|.::.|.:
  Rat   394 ETDPGLAALPQQLLFVHQGET-DLKELHWHPQCPGVLISTA 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-55	NP_524354.1	CAF1C_H4-bd	23..92	CDD:403473	17/85 (20%)
		WD40	127..408	CDD:421866	85/301 (28%)
		WD40 repeat	132..179	CDD:293791	9/59 (15%)
		WD40 repeat	184..228	CDD:293791	13/47 (28%)
		WD40 repeat	235..274	CDD:293791	12/43 (28%)
		WD40 repeat	280..318	CDD:293791	13/39 (33%)
		WD40 repeat	324..375	CDD:293791	17/55 (31%)
		WD40 repeat	381..406	CDD:293791	4/18 (22%)
Grwd1	NP_001012067.1	CAF1C_H4-bd	44..111	CDD:289068	19/83 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..141		9/40 (23%)
		WD40	<193..>382	CDD:225201	59/200 (30%)
		WD40	205..>383	CDD:295369	60/189 (32%)
		WD 1	211..251		15/46 (33%)
		WD40 repeat	216..257	CDD:293791	13/47 (28%)
		WD 2	258..298		15/43 (35%)
		WD40 repeat	264..303	CDD:293791	11/42 (26%)
		WD 3	305..344		15/39 (38%)
		WD40 repeat	310..349	CDD:293791	13/39 (33%)
		WD 4	350..390		11/39 (28%)
		WD40 repeat	355..406	CDD:293791	14/50 (28%)
		WD 5	411..444		6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D831322at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920