DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Caf1-55 and prw1

DIOPT Version :9

Sequence 1:	NP_524354.1	Gene:	Caf1-55 / 41836	FlyBaseID:	FBgn0263979	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_594864.1	Gene:	prw1 / 2541804	PomBaseID:	SPAC29A4.18	Length:	431	Species:	Schizosaccharomyces pombe

Alignment Length:	431	Identity:	173/431 - (40%)
Similarity:	249/431 - (57%)	Gaps:	25/431 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SDNAAESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPD--VTKQDGKDYSV 67
            |..|..|.:...:|:.|||||||||||:||||||::|.|||||.::.||.|:  :..:.|  |:.
pombe    10 SKQAQASEEGINQEKCINEEYKIWKKNSPFLYDLIITRALEWPCMSLQWYPEQQIFAEHG--YTE 72

  Fly    68 HRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNE-------KGEFGGFGSVCGKIEIEIKI 125
            .::.||......:..|.:||:|||          |.|:       :|...|..|.. ::.|....
pombe    73 QKMFLGVRADVGKYLLAVASIQLP----------YLNQTVPPTTMEGASAGDESSL-RVNISNLY 126

  Fly   126 NHEGEVNRARYMPQ-NACVIATKTPSSDVLVFDYTKHPSKPEPS-GECQPDLRLRGHQKEGYGLS 188
            :|...|..|:.||| ::||.......:||||||.....|....| ...:|..||..|.:....:.
pombe   127 SHPESVCSAKLMPQDDSCVATVGNYHNDVLVFDKESFESYSSASESPLKPKYRLTKHTQPCTSVC 191

  Fly   189 WNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADD 253
            ||....|.|:|.|.|.|:..||:||..:.......|...:.|...|.||.:|..|:.|..||:.|
pombe   192 WNFLSKGTLVSGSQDATLSCWDLNAYNESDSASVLKVHISSHEKQVSDVRFHYKHQDLLASVSYD 256

  Fly   254 QKLMIWDTRNNNTS-KPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF 317
            |.|.:.|.|..:.| ||:.:|.||:..::.::|||:::|||||.|.|||:||||||||..:||:.
pombe   257 QYLHVHDIRRPDASTKPARSVHAHSGPIHSVAFNPHNDFILATCSTDKTIALWDLRNLNQRLHTL 321

  Fly   318 ESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKIS 382
            |.|:|.:.::.:|||.|.||||:..|||..|||||:|||:|..|:|:||||||||:|||||:...
pombe   322 EGHEDIVTKISFSPHEEPILASTSADRRTLVWDLSRIGEDQPAEEAQDGPPELLFMHGGHTSCTI 386

  Fly   383 DFSWNPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPAS 423
            |..|.||..|.:.:.:||||:|:|..:.:::.:|:.|..|:
pombe   387 DMDWCPNYNWTMATAAEDNILQIWTPSRSIWGNEQLEEDAT 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-55	NP_524354.1	CAF1C_H4-bd	23..92	CDD:403473	33/70 (47%)
		WD40	127..408	CDD:421866	124/283 (44%)
		WD40 repeat	132..179	CDD:293791	17/48 (35%)
		WD40 repeat	184..228	CDD:293791	13/43 (30%)
		WD40 repeat	235..274	CDD:293791	15/39 (38%)
		WD40 repeat	280..318	CDD:293791	22/37 (59%)
		WD40 repeat	324..375	CDD:293791	30/50 (60%)
		WD40 repeat	381..406	CDD:293791	10/24 (42%)
prw1	NP_594864.1	CAF1C_H4-bd	28..96	CDD:289068	32/69 (46%)
		WD40	99..>410	CDD:225201	128/311 (41%)
		WD40	110..410	CDD:295369	126/300 (42%)
		WD40 repeat	133..182	CDD:293791	17/48 (35%)
		WD40 repeat	187..231	CDD:293791	13/43 (30%)
		WD40 repeat	238..276	CDD:293791	15/37 (41%)
		WD40 repeat	284..322	CDD:293791	22/37 (59%)
		WD40 repeat	328..379	CDD:293791	30/50 (60%)
		WD40 repeat	384..410	CDD:293791	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0264
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53987
OrthoFinder	1	1.000	-	-		FOG0001098
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X748
TreeFam	1	0.960	-	-
	7	6.880