DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Caf1-55 and pcf3

DIOPT Version :9

Sequence 1:	NP_524354.1	Gene:	Caf1-55 / 41836	FlyBaseID:	FBgn0263979	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_593810.1	Gene:	pcf3 / 2541656	PomBaseID:	SPAC25H1.06	Length:	408	Species:	Schizosaccharomyces pombe

Alignment Length:	412	Identity:	137/412 - (33%)
Similarity:	211/412 - (51%)	Gaps:	48/412 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDYSVHRLILGTHTSDEQ-N 81
            |..|:|::..||||:..||:|::|..|.||||:.|||..:.....|....:||:||||.::.. |
pombe    17 ENQISEDHFRWKKNSKHLYNLLITRTLTWPSLSIQWLSAMESITEKAVLKNRLLLGTHAAEGMPN 81

  Fly    82 HLLIASVQLPSEDAQFDGS------HYDNEKGEFGGFG--SVCGKIEIEIKINHEGEVNRARYMP 138
            .|.:|.:.||    .|:.:      ||:.:.||.||:.  ..| |.:|..:|.|.|:|||.|:||
pombe    82 FLQLADLDLP----DFNQTILDPVKHYNEDTGELGGYSMQHSC-KFQISQRILHNGDVNRVRHMP 141

  Fly   139 QNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDD 203
            ||..:|||.:...:..:||.||:.|.  |:.|..|::.|.||:|||:|||||...|..|::|::|
pombe   142 QNPNIIATMSSCGNAYIFDRTKYTSM--PAEEFLPNISLIGHKKEGFGLSWNRQQNCRLVTAAND 204

  Fly   204 HTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSK 268
            ..|..||:|...::.|.:.....|....:.|.||.:|..|.:|:.:|.|:....|.|.|...|.
pombe   205 SKILEWDLNNFSRDTRCLTPVKDFHYDDSPVNDVEYHPHHTNLYIAVNDNGIAFICDNRLQQTC- 268

  Fly   269 PSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL-KLKLHSFESHKDEIFQV----- 327
             |.||.| :..:..:..||....:.|.|| ::.:.||||||| |...::.|...|...:|
pombe   269 -SKTVKA-SNPLFSVRHNPSIATLFALGS-EQDLQLWDLRNLNKSVFNTSEDLSDNRLKVPSRLT 330

  Fly   328 ------QWS-PHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFS 385
                  .|| .|:..|:  |......:||:.:|..             .|.|:|.||...:::..
pombe   331 LGGTSLSWSWRHSGRIV--SACQEYCYVWNFNKAN-------------PLEFVHAGHKGTVNEVD 380

  Fly   386 WNPNEPWIICSVSEDNIMQVWQ 407
            ::|.|...|.||::||.:.:|:
pombe   381 FDPFEAQCIASVADDNELHIWK 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-55	NP_524354.1	CAF1C_H4-bd	23..92	CDD:403473	28/69 (41%)
		WD40	127..408	CDD:421866	95/294 (32%)
		WD40 repeat	132..179	CDD:293791	19/46 (41%)
		WD40 repeat	184..228	CDD:293791	15/43 (35%)
		WD40 repeat	235..274	CDD:293791	13/38 (34%)
		WD40 repeat	280..318	CDD:293791	13/38 (34%)
		WD40 repeat	324..375	CDD:293791	11/62 (18%)
		WD40 repeat	381..406	CDD:293791	7/24 (29%)
pcf3	NP_593810.1	CAF1C_H4-bd	22..91	CDD:289068	27/68 (40%)
		WD40	<123..404	CDD:225201	97/301 (32%)
		WD40 repeat	135..180	CDD:293791	19/46 (41%)
		WD40	<177..402	CDD:295369	73/243 (30%)
		WD40 repeat	185..225	CDD:293791	15/39 (38%)
		WD40 repeat	236..271	CDD:293791	12/36 (33%)
		WD40 repeat	278..315	CDD:293791	13/37 (35%)
		WD40 repeat	333..370	CDD:293791	10/51 (20%)
		WD40 repeat	376..401	CDD:293791	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0264
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53987
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101102
Panther	1	1.100	-	-	O	PTHR22850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.780