DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-55 and Rbbp4

DIOPT Version :9

Sequence 1:	NP_524354.1	Gene:	Caf1-55 / 41836	FlyBaseID:	FBgn0263979	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_033056.2	Gene:	Rbbp4 / 19646	MGIID:	1194912	Length:	425	Species:	Mus musculus

Alignment Length:	419	Identity:	378/419 - (90%)
Similarity:	403/419 - (96%)	Gaps:	4/419 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVDRSDNAAESFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTKQDGKDY 65
            |.|:.    .:|||||||||||||||||||||||||||||||||||||||||||||||:.:|||:
Mouse     1 MADKE----AAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDF 61

  Fly    66 SVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIEIEIKINHEGE 130
            |:|||:||||||||||||:|||||||::|||||.||||:|||||||||||.||||||||||||||
Mouse    62 SIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGE 126

  Fly   131 VNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNG 195
            ||||||||||.|:||||||||||||||||||||||:|||||.|||||||||||||||||||||:|
Mouse   127 VNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSG 191

  Fly   196 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWD 260
            :|||||||||||||||:|.|||.:|:|||.||||||||||||:||||||||||||||||||||||
Mouse   192 HLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWD 256

  Fly   261 TRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIF 325
            ||:||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   257 TRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIF 321

  Fly   326 QVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNE 390
            |||||||||||||||||||||:||||||||||||.||||||||||||||||||||||||||||||
Mouse   322 QVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNE 386

  Fly   391 PWIICSVSEDNIMQVWQMAENVYNDEEPE 419
            ||:||||||||||||||||||:||||:||
Mouse   387 PWVICSVSEDNIMQVWQMAENIYNDEDPE 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-55	NP_524354.1	CAF1C_H4-bd	23..92	CDD:403473	61/68 (90%)
		WD40	127..408	CDD:421866	262/280 (94%)
		WD40 repeat	132..179	CDD:293791	42/46 (91%)
		WD40 repeat	184..228	CDD:293791	35/43 (81%)
		WD40 repeat	235..274	CDD:293791	35/38 (92%)
		WD40 repeat	280..318	CDD:293791	37/37 (100%)
		WD40 repeat	324..375	CDD:293791	48/50 (96%)
		WD40 repeat	381..406	CDD:293791	23/24 (96%)
Rbbp4	NP_033056.2	CAF1C_H4-bd	19..88	CDD:403473	61/68 (90%)
		WD40	122..403	CDD:421866	262/280 (94%)
		WD 1	122..155		30/32 (94%)
		WD40 repeat	128..175	CDD:293791	42/46 (91%)
		WD 2	175..206		28/30 (93%)
		WD40 repeat	180..224	CDD:293791	35/43 (81%)
		WD 3	225..256		29/30 (97%)
		WD40 repeat	231..270	CDD:293791	35/38 (92%)
		WD 4	271..302		30/30 (100%)
		WD40 repeat	276..314	CDD:293791	37/37 (100%)
		WD 5	315..346		29/30 (97%)
		WD40 repeat	320..371	CDD:293791	48/50 (96%)
		WD 6	372..403		29/30 (97%)
		WD40 repeat	377..402	CDD:293791	23/24 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	167	1.000	Domainoid score	I3853
eggNOG	1	0.900	-	-		E1_KOG0264
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21153
Inparanoid	1	1.050	808	1.000	Inparanoid score	I486
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53987
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001098
OrthoInspector	1	1.000	-	-		oto93929
orthoMCL	1	0.900	-	-		OOG6_101102
Panther	1	1.100	-	-	LDO	PTHR22850
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R552
SonicParanoid	1	1.000	-	-		X748
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860