DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and RABGAP1L

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_001353375.1	Gene:	RABGAP1L / 9910	HGNCID:	24663	Length:	1051	Species:	Homo sapiens

Alignment Length:	681	Identity:	141/681 - (20%)
Similarity:	243/681 - (35%)	Gaps:	164/681 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 HTRKLQNLGSEDDLGELPPMMEELSVADGLRPNPGGPFSALTASMWPQEILAKLGGGAELASGPN 85
            ||    |.|  |.:.|:..:..|....:.:.|..||      ..|.||:..|:.....||:||..
Human   447 HT----NAG--DAIYEVVSLQRESDKEEPVTPTSGG------GPMSPQDDEAEEESDNELSSGTG 499

  Fly    86 DQPEYRFDEFGFRVEEEDGPEQ---SSNKLLSIPFVEDAQQRLQWIAHLEFSHNKEAAELSWEHV 147
            |             ..:|.||:   |..:||.           :|       |:...|
Human   500 D-------------VSKDCPEKILYSWGELLG-----------KW-------HSNLGA------- 526

  Fly   148 DVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHD-----------IVKASSND 201
                 |.:.|..:|:.|:|..|||::|..|:|.           ||           |.|.|:.:
Human   527 -----RPKGLSTLVKSGVPEALRAEVWQLLAGC-----------HDNQAMLDRYRILITKDSAQE 575

  Fly   202 QLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFME 266
            .::|     :|:.|..|.:..|.:..|.|...|.:|.:..:....|||||||...:.|.|||.|.
Human   576 SVIT-----RDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMP 635

  Fly   267 EENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLITLHWF 331
            ||.||.::..|:.|......|.:....:......:..|:...|..:.......::|..:....||
Human   636 EEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWF 700

  Fly   332 LTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDL--------------------KH 376
            ||||.....:.::..|.|....||..::|.:.|.:||..::||                    :.
Human   701 LTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRA 765

  Fly   377 LENSAQIFNSLSDIPGEVTDVEVLFR--QALEVGGSLSQTVIDTHRRRHLAYLMADQGHQIGNPE 439
            .||:.::.....:|......::...:  |.:.......:..:|.::|.:.....|....:..|.:
Human   766 EENARRLMEQACNIKVPTKKLKKYEKEYQTMRESQLQQEDPMDRYKRENRRLQEASMRLEQENDD 830

  Fly   440 AAPNLPKQQLARR----QVRKSKSIL--EAFLFRGDGNEGDQLKNKNIRQTEILVDL-REAILKV 497
            .|..|...::|.|    |......:|  |..|.:....|.::.|.|...:|..|.:: |:.:.|.
Human   831 LAHELVTSKIALRNDLDQAEDKADVLNKELLLTKQRLVETEEEKRKQEEETAQLKEVFRKQLEKA 895

  Fly   498 GRHFITIEPKLAGHIQLTANYSTE----------------------SHAKD---HENFINVARTR 537
            ..........:|.:.|:.:..||.                      .|..|   .|..:.:|.|
Human   896 EYEIKKTTAIIAEYKQICSQLSTRLEKQQAASKEELEVVKGKMMACKHCSDIFSKEGALKLAAT- 959

  Fly   538 KRRAKALHDFERHDDDELGFRRNDI------ITIISQKDEHCWVGELNGLRGWFPAKFVELLDER 596
            .|..:.:...:..|..:...|..::      :.::..|   |.:.||...||       .|::|
Human   960 GREDQGIETDDEKDSLKKQLREMELELAQTKLQLVEAK---CKIQELEHQRG-------ALMNE- 1013

  Fly   597 SKLYTSAGDDAISETVTDLVRGT----LAPA 623
               ..:|.:...|:|:..:...|    |.||
Human  1014 ---IQAAKNSWFSKTLNSIKTATGTQPLQPA 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	61/244 (25%)
		SH3_SGSM3	540..592	CDD:212747	8/57 (14%)
		RUN	619..773	CDD:280855	4/9 (44%)
RABGAP1L	NP_001353375.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		PTB_Rab6GAP	129..257	CDD:269922
		DUF3694	290..421	CDD:315198
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..503		13/60 (22%)
		RabGAP-TBC	541..744	CDD:306939	57/218 (26%)
		DUF3084	800..>1018	CDD:331293	39/232 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810