DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and SGSM2

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	XP_011522403.1	Gene:	SGSM2 / 9905	HGNCID:	29026	Length:	1103	Species:	Homo sapiens

Alignment Length:	429	Identity:	93/429 - (21%)
Similarity:	140/429 - (32%)	Gaps:	115/429 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SEDDLGELPPMMEELSVADGLRPNP---GGPFSALTASMWPQEILAKLGGGAELASGPNDQPEYR 91
            |.|||....|...|.|     ||.|   .||.:..||.:..|.       ..|..|..:..|..|
Human   750 SVDDLEPPEPQDPEDS-----RPKPEQEAGPGTPGTAVVEQQH-------SVEFDSPDSGLPSSR 802

  Fly    92 -----------FDE---FGFRVEEEDGPEQSSNKLLSIPFVEDAQQRLQWIAHLEFSHNKEAAEL 142
                       .||   .||..|:..|.|.||..                         ..||..
Human   803 NYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGP-------------------------GPAAHT 842

  Fly   143 SWEHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMTSK 207
            ..|..|   |..||         |.....:....|:...|.....|..  |.|       .:...
Human   843 LREPQD---PSQEK---------PQAGELEAGEELAAVCAAAYTIELL--DTV-------ALNLH 886

  Fly   208 QIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEENAFW 272
            :|:||:.|.......|:.||   :.|||.::....|...|:||.||...::|.||:
Human   887 RIDKDVQRCDRNYWYFTPPN---LERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLV--------- 939

  Fly   273 MMATIVEDLLPASYYSSTLLGIQ---ADQRVMHTLIANYLSSV---DESL-----RKHDIELSLI 326
               |:..|.|..|.:|..:..:.   .:...|.|..||..|.:   |..|     :..|......
Human   940 ---TLDNDQLAYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYF 1001

  Fly   327 TLHWFLTLFANVVHMKILVRIWDWFFYEGSI-----VLFQLTLGMLKVKEQDLKHLENS------ 380
            ...|||..|...:..:.:..:|:..:....|     ||| :.|.:::...:.::  :|:
Human  1002 CYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLF-IALALVEAYREIIR--DNNMDFTDI 1063

  Fly   381 AQIFNSLSDIPGEVTDVEVLFRQALEVGGSLSQTVIDTH 419
            .:.||:|...|..|..:.:..|.....|.|.::...:.|
Human  1064 IKFFNALHVSPQNVLSITMPRRSCGLPGTSSTRYFPENH 1102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	48/229 (21%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
SGSM2	XP_011522403.1	RUN	90..235	CDD:280855
		PH_RUTBC	302..470	CDD:275431
		TBC	<885..1053	CDD:214540	42/183 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900