Protein Alignment CG12241 and TBC1D5

DIOPT Version :9

• Sequence 1: NP_650432.1
• Gene: CG12241 / 41834
• FlyBaseID: FBgn0038304
• Length: 804
• Species: Drosophila melanogaster
• Sequence 2: NP_001127853.1
• Gene: TBC1D5 / 9779
• HGNCID: 19166
• Length: 817
• Species: Homo sapiens
• Alignment Length: 682
• Identity: 116/682 - (17%)
• Similarity: 210/682 - (30%)
• Gaps: 289/682 - (42%)

  Fly   122 QQRLQWIAHLE-----FSHNKEAAELSWEHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGAL 181
            |.:.|||:.:|     :|:.||.      |:.                .|..:..|..:.::..|
Human   100 QDKSQWISRIEELRAWYSNIKEI------HIT----------------NPRKVVGQQDLMINNPL 142

  Fly   182 AKKQKSETSYHDIVKASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLF- 245
            ::.:.|      :......|:.:.| .||:|:.|..|....|...|      :|:||..:.:.:
Human   143 SQDEGS------LWNKFFQDKELRS-MIEQDVKRTFPEMQFFQQEN------VRKILTDVLFCYA 194

  Fly   246 ---PDIGYCQGTGVIVACLLLFME----------------------------EENAFWMMATIVE 279
               ..:.|.||...::|.::..:.                            |.:|:.:.:.::|
Human   195 RENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLME 259

  Fly   280 DLLPASYYSSTLLGIQADQRVMHT---------------LIANYLSSVDESLRKHDIEL------ 323
            ...|  ::|:.....|..:..:.|               ::.......|..|:||||||
Human   260 TAEP--WFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNR 322

  Fly   324 -----SLITLHWFLTLFANVVHMKILVRIWDWFFYEG-----------SIVL----------FQL 362
                 .:..|.|...||.....::.|:.:||..|.:|           :::|          :|.
Human   323 LEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQT 387

  Fly   363 TLGML----------------------------------------KVKEQDLKHLE--------- 378
            .||:|                                        |.:..||.:..
Human   388 CLGLLMHYPFIGDVHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGAPL 452

  Fly   379 NSAQIFNSLSDI----------PGEVTDVEVLFRQALEVGG--------SLSQTVIDTHRRRHLA 425
            |..::.|||.:.          ||             ..||        |.|..||.|..
Human   453 NINKVSNSLINFGRKLISPAMAPG-------------SAGGPVPGGNSSSSSSVVIPTRT----- 499

  Fly   426 YLMADQGHQIGNPEAAPNLPKQQLARRQVRKSKSILEAFLFRGDGNEGDQ--------------- 475
                       :.||..:..:||..::::.||:| :...|.:||...|..
Human   500 -----------SAEAPSHHLQQQQQQQRLMKSES-MPVQLNKGDVVTGSDAQVSVPVQTLTDLQG 552

  Fly   476 LKNKNIRQTEILVDLREAILKVGRHFITIEPKLAGHIQLTANYSTESHAKDHENFINVARTRKR- 539
            |.:|||..:..:..     |..||.|....|              .|..|....|.|::|:|..
Human   553 LSSKNISSSPSVES-----LPGGREFTGSPP--------------SSATKKDSFFSNISRSRSHS 598

  Fly   540 RAKALHDFERHDDDELGFRRNDIITIISQKDEHCWVGELNGLRGW--FPAKFV------------ 590
            :.....:.|...:.::.|.:                |:||.|...  :.||.:
Human   599 KTMGRKESEEELEAQISFLQ----------------GQLNDLDAMCKYCAKVMDTHLVNIQDVIL 647

  Fly   591 -ELLDERSKLYTS-AGDDAISETVTDLVRGTL 620
             |.|::..::..| ||    .:.:.|:::|:|
Human   648 QENLEKEDQILVSLAG----LKQIKDILKGSL 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	51/332 (15%)
		SH3_SGSM3	540..592	CDD:212747	8/66 (12%)
		RUN	619..773	CDD:280855	1/2 (50%)
TBC1D5	NP_001127853.1	TBC	79..381	CDD:214540	54/317 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900