Protein Alignment CG12241 and MSB4

DIOPT Version :10

• Sequence 1: NP_650432.1
• Gene: CG12241 / 41834
• FlyBaseID: FBgn0038304
• Length: 804
• Species: Drosophila melanogaster
• Sequence 2: NP_014529.1
• Gene: MSB4 / 854037
• SGDID: S000005472
• Length: 492
• Species: Saccharomyces cerevisiae
• Alignment Length: 585
• Identity: 138/585 - (23%)
• Similarity: 206/585 - (35%)
• Gaps: 177/585 - (30%)

  Fly     6 SIFGRDHEGYVGREEHTRKLQNLGSEDDLGELPPMMEELSVADGLRPNPGGPFSALTASMWPQEI 70
            |.|..|...|        .:.:|..:||.|:....:|...:...........|::|        |
Yeast    24 SSFNEDDANY--------SVLDLYDDDDEGDDSSTVERKEILTTRELEKAKAFTSL--------I 72

  Fly    71 LAKLGGGAELASGPNDQPEYRFDEFGFRVEEEDGPEQSSNKLLSIPFVEDAQQRLQWIAHLEFSH 135
            :|              .|| .||.:||           |.|..   |:...:....|   .|::.
Yeast    73 MA--------------DPE-NFDRYGF-----------SKKGY---FISQEEYDKWW---TEYNR 105

  Fly   136 NKEAAELSWE----------HVD---VMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKS 187
            ..|..:..||          |.|   |...||::|...||:|||...|...|...:|. .::..:
Yeast   106 YTERRKKKWENFLLKNKIELHNDNPLVYPARTDELSKFVRKGIPAEWRGNAWWYFAGG-QRQLDA 169

  Fly   188 ETSYHDIVKASSNDQLMTSKQ---IEKDLLRILPTN-----ACFSNPNGTGIPRLRRILRGIAWL 244
            ....:|.:|:...:..::.|.   ||:||.|..|.|     ..|.|.....|..|||:|...:..
Yeast   170 NVGVYDRLKSDCREGAVSGKDMEAIERDLYRTFPDNIHFHKESFQNGEPAIIRSLRRVLMAFSVY 234

  Fly   245 FPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYL 309
            ...|||||....:|..||||||||.||||:..|....|| ..|.|.|.|...||.|:...|..||
Yeast   235 DKTIGYCQSMNFLVGLLLLFMEEEKAFWMLVIITGKYLP-GVYESDLEGANVDQGVLVLCIKEYL 298

  Fly   310 SSVDESLRKHDIE-----------------------LSLITLHWFLTLFANVVHMKILVRIWDWF 351
            ..:...:....:.                       |:|.|..||::.|..||.::..:||||..
Yeast   299 PEIWSHIESSYMNGNGSTDQISGPASGEEYLCRLPTLTLCTASWFMSCFVGVVPIETTLRIWDCL 363

  Fly   352 FYEGSIVLFQLTLGMLKVKEQDLKHLENSAQIFNSLSDIPGEVTDVEVLFRQALEVGGSLSQTVI 416
            |||.|..||::.||:||:.|.:.  ||:.:|                .||||
Yeast   364 FYEESHFLFKVALGILKLSESEF--LESKSQ----------------KLFRQ------------- 397

  Fly   417 DTHRRRHLAYLMADQGHQIGNPEAAPNLPKQQLARRQVRKSKSILEAFLFRGDGNEGD----QLK 477
                                                        ..::.| |..|:.|    :||
Yeast   398 --------------------------------------------YSSYTF-GGSNDSDSTFKRLK 417

  Fly   478 NKNIRQTEILVDLREAILKVGRHFIT---IEPKLAGHIQLTANYSTESHAKDHENFINVARTRKR 539
            ||...|.|..:::.:.|....:..:.   |..|:....::..|..|:........::.:||.|:|
Yeast   418 NKIKTQEEADMEILQVIQNFPKRLLNPNDIFEKVLMKKKVALNGITQEKIDRGREYVAMARNRQR 482

  Fly   540  539
            Yeast   483  482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	79/244 (32%)
		SH3_SGSM3	540..592	CDD:212747	138/585 (24%)
		RUN_SGSM3	570..783	CDD:439050
MSB4	NP_014529.1	COG5210	<53..461	CDD:227535	123/525 (23%)