DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG12241 and MDR1

DIOPT Version :9

Sequence 1:NP_650432.1 Gene:CG12241 / 41834 FlyBaseID:FBgn0038304 Length:804 Species:Drosophila melanogaster
Sequence 2:NP_011614.1 Gene:MDR1 / 852992 SGDID:S000003332 Length:950 Species:Saccharomyces cerevisiae


Alignment Length:667 Identity:146/667 - (21%)
Similarity:254/667 - (38%) Gaps:157/667 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 HLEFSHN----KEAAELS-W------EHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAK 183
            |.::..|    ||.|:|. |      ...::.:.:|...|.::|.|:|:.:|.::|...|||:..
Yeast   199 HFKYPGNPTMVKEKAKLRLWFDYFRENGRNLAVVQTPMFRKLIRIGVPNRMRGEIWELCSGAMYM 263

  Fly   184 KQKSETSYHDIVKASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDI 248
            :..:...|..|:..::........:|||||.|.||..:.:....  ||.|||.:|...:|..||:
Yeast   264 RYANSGEYERILNENAGKTSQAIDEIEKDLKRSLPEYSAYQTEE--GIQRLRNVLTAYSWKNPDV 326

  Fly   249 GYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVD 313
            ||||...::||..|:||.||.|||.:..:.:..:| .|||.|:.|...||||..:.:.:.:..:.
Yeast   327 GYCQAMNIVVAGFLIFMSEEQAFWCLCNLCDIYVP-GYYSKTMYGTLLDQRVFESFVEDRMPVLW 390

  Fly   314 ESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLE 378
            |.:.:|||:||:::|.|||:||...:.::..|||.|.||..|||.|||:.|.:||:...|:...:
Yeast   391 EYILQHDIQLSVVSLPWFLSLFFTSMPLEYAVRIMDIFFMNGSITLFQVALAVLKINADDILQAD 455

  Fly   379 NSAQIFNSLSDIPGEVTDVEVLFRQALEVGGSLSQTVIDTHRRRHLAYLMADQGHQIGNPEAAPN 443
            :.......:                                  :|....:....|    |:::  
Yeast   456 DDGMFIAII----------------------------------KHYFQTLGQSAH----PDSS-- 480

  Fly   444 LPKQQLARRQVRKSKSIL-EAFLFRGDGNEGDQLKNKNIRQTEILVDLREAILKVGRHFITIEPK 507
                .:..||:.|.:.:| .||            |..::...|:.:..|....|  ..|..||..
Yeast   481 ----DIKYRQITKFQELLVTAF------------KEFSVISEEMAMHARHKYEK--GIFQNIETF 527

  Fly   508 L----AGHIQLTANYSTESHAKDHENFINVARTRK--------------------RRAKALHDFE 548
            :    ..|:..|.|.|::..:..::.|.....|.|                    :...:....|
Yeast   528 MKRTQLRHMPKTFNLSSDDLSNIYDMFYQSIETYKISMGTGSSNMGFEVFIQFLSKFCDSCRPCE 592

  Fly   549 RHDDDELGFRRNDIITIISQKDEHCWVGEL------NGLRGWFPAKFVELLDERSKLYTSAGDDA 607
            :..|.....::.:.:..:....:...:|||      .||........::.::....||.:.||..
Yeast   593 KDKDPAFRKQKRNFLQRLFDNWDSAHIGELTLNDVVTGLDKLVTVDLLQAINYFFSLYDTDGDGE 657

  Fly   608 I-SETVTDLVRGTLAPAIKAFLEHGMKRPTFLGGPIHPW---LYIEEAATREVEKDFE------- 661
            : .|.|..|..|.|...                   .||   .|::....:.:|.|..       
Yeast   658 LHREEVLQLSEGLLLLT-------------------EPWKSGRYVDLLTKKRIEDDIAENIIKES 703

  Fly   662 ----SVYSRLVLCKTYRLDEDG-KVLTPEELLYRC-------------------VQAINQTHDDA 702
                :..:::.|.....:||:. ||...|..|...                   |..|:.:.|:.
Yeast   704 GGEIATMNQIELPTGVTIDEEKYKVEQAERYLKAASNFLQRSFEYAKAVDLAEEVNLIDLSDDEG 768

  Fly   703 HAQMDVKLRSLICLGLN 719
            ..:..||.:.|..:..|
Yeast   769 EEKRTVKQKQLESIKAN 785

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12241NP_650432.1 TBC 161..375 CDD:214540 79/213 (37%)
SH3_SGSM3 540..592 CDD:212747 7/57 (12%)
RUN 619..773 CDD:280855 20/135 (15%)
MDR1NP_011614.1 COG5210 23..531 CDD:227535 104/392 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5210
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R540
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.840

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