DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and AT2G39280

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_001189710.1	Gene:	AT2G39280 / 818513	AraportID:	AT2G39280	Length:	772	Species:	Arabidopsis thaliana

Alignment Length:	719	Identity:	156/719 - (21%)
Similarity:	266/719 - (36%)	Gaps:	171/719 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RDHEGYVGREEHT---RKLQNLGSEDDLGELPPMME--ELSVADGLRPNPGGPFSALTASMWPQE 69
            ||..|:..|.:|.   |:..|:..|:::........  |.....|:.|..|   |:....:.|.|
plant    41 RDAYGFSVRPQHVQRYREYVNIYKEEEVERSARWSNFLEFHAESGVSPTNG---SSENTHVNPSE 102

  Fly    70 ILAK----LGGGAELASGPNDQPEYRFDEFGFRVEEEDGPEQSSN--KLL-------SIPFVED- 120
            ...|    |..|||......|:|.........| ||::.|.:..|  |:.       |:..:||
plant   103 SDKKKEKELNKGAERKDLNADKPGSDLTPGNAR-EEDEVPNREKNVHKVQLWAEIRPSLQAIEDL 166

  Fly   121 -------------AQQRLQWIAHLEFSHNKEAAELSWEH------------------------VD 148
                         .:|..|.:..|..:...|:::...|:                        |.
plant   167 MSVRVKMKGDSTNGEQEAQKLNSLASTDETESSKGVCENDSEDEFYDAERSDPIQDGSSDGTSVS 231

  Fly   149 VM------------LPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIV------ 195
            .|            .|..::|..::..|.|..||.::|...:|  .||::.:..|.:::
plant   232 SMSAAADAASLVSACPWKDELEVLIHGGAPMALRGELWQAFAG--VKKRRVKNYYQNLLAADSLG 294

  Fly   196 -------------KASSNDQLMTSK----QIEKDLLRILPTNAC----FSNPNGTGIPRLRRILR 239
                         |.||.|.|...:    ||||||.|..|.:..    |.|       .|||:|.
plant   295 NDIEQELMQHTDEKGSSTDPLSVVEKWKGQIEKDLPRTFPGHPALDDDFRN-------ALRRLLT 352

  Fly   240 GIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTL 304
            ..|...|.:||||......|.|||.|.||||||.:..|::|.. ..|||..:|..|.||||:..|
plant   353 AYARHNPSVGYCQAMNFFAALLLLLMPEENAFWSLTGIIDDYF-HDYYSEEMLESQVDQRVLEEL 416

  Fly   305 IANYLSSVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWDWFFYEGS-IVLFQLTLGMLK 368
            :......:...|....::::.:|..||||:|.|::..:.::|:||...:||: ::||:..|.:::
plant   417 LRERFPKLVHHLDYLGVQVACVTGPWFLTIFINMLPWESVLRVWDVLLFEGNRVMLFRTALALME 481

  Fly   369 VKEQDLKHLENSAQIFNSLSDIPGEVTDVEVLFRQALEVGGSLSQTVIDTHRRRHLAYLMA---- 429
            .....|...::.......|..:.|...|...|...|.....::.::.:...|.:|...::|
plant   482 FYGPALVTTKDIGDAVTLLQSMTGSTFDSSQLVFTACMGYQNVHESKLQELRSKHRPAVIAAFEE 546

  Fly   430 ------------DQGHQIGNPEAAPN---LPKQQLARRQVRKSKS--------------ILEAFL 465
                        |...::.|.:..||   ..|..|:...:.:|:|              ..|..:
plant   547 RLKGLQAWRDSKDTATKLHNSKQDPNSVLASKASLSNGSLSRSESGSSYADDIFISLTGDCEIDI 611

  Fly   466 F---RGDGNEGDQLKNKN---IRQTEILVDLREAILKVGRHFITIEPKLAGHIQLTANYSTE--- 521
            |   :|.|.....|:.|.   :|..|:.|.|.|.:.:..|.      :|...|:......||
plant   612 FQDLQGQGELHKLLQEKRSALLRAEELEVALMEMVKQDNRR------QLKAKIEQLEQGVTELRR 670

  Fly   522 --SHAKDHEN-FINVARTRKRRAKALHDFERHDDDELGFRR----------NDIITIISQKDEHC 573
              |..::.|: .|.|....::..|...|..|..:.:...:|          .:.:..:::.:|..
plant   671 LVSDKREQESAMIQVLMRMEQEHKVTEDARRLAEQDAATQRYAAEVLQEKYEEAVAALAEMEERA 735

  Fly   574 WVGE 577
            .:.|
plant   736 VMAE 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	73/241 (30%)
		SH3_SGSM3	540..592	CDD:212747	6/48 (13%)
		RUN	619..773	CDD:280855
AT2G39280	NP_001189710.1	RabGAP-TBC	321..487	CDD:278964	59/173 (34%)
AT2G39280	NP_001189710.1	PspA	<620..744	CDD:224755	22/126 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22957
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920