DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and AT2G37290

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_001189697.1	Gene:	AT2G37290 / 818306	AraportID:	AT2G37290	Length:	916	Species:	Arabidopsis thaliana

Alignment Length:	779	Identity:	169/779 - (21%)
Similarity:	280/779 - (35%)	Gaps:	196/779 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RDHEGYVGRE-EHTRKLQNLGSEDDLGELPPMMEELSVADGLRPNPGGPFSALTASMWPQEI--- 70
            :|.|..||.| |...:.|:...::.:..:....||..||:..:...|....|...:..|:.:
plant   158 KDKESSVGSESESDEEQQSQAVKEPVDHVHIQQEEKLVAEEDKCESGHEEKAQKETKAPRSVIEW 222

  Fly    71 ------LAKL-----GGGAELASGPNDQPEYRFDEFGFRVE------EEDG-----PEQSSNKLL 113
                  ||.:     .....:.|..|.|... .|:....::      ||.|     .|.|:::..
plant   223 AHIRPCLASIEDMMCSRVKNVKSTKNGQKNI-VDDHASSIKESLSSIEESGENDRDSETSTSRSH 286

  Fly   114 SIPFVEDAQQRLQWIAHLEFSHNKEAAELSWEHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLS 178
            ||....:||..:.                    .:...|..|:|..:||.|:|..||.::|....
plant   287 SIKEENEAQGSVS--------------------PEPFFPWYEELEVLVRLGVPKDLRGEVWQAFV 331

  Fly   179 GALAKKQKSETSYHDIV-------KASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRR 236
            |  .|.::.|..|.|::       :.||:.|....||||||:.|..|.:...   |..|...|||
plant   332 G--VKARRVERYYQDLLAQITNSDENSSDVQRKWKKQIEKDIPRTFPGHPAL---NENGRDSLRR 391

  Fly   237 ILRGIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVM 301
            ||...|...|.:||||........|||.|.||||||.:..|::|... .||:..::..|.||.|.
plant   392 ILLAYACHNPSVGYCQAMNFFAGLLLLLMPEENAFWTLVGIIDDYFD-GYYTEEMIESQVDQLVF 455

  Fly   302 HTLIANYLSSVDESLRKHDIELSL-----------------------------------ITLHWF 331
            ..|:......:. ||...||::||                                   |:..||
plant   456 EELMRERFPKLG-SLFSSDIQVSLHIFLPYTEQCDRFFYSNNPPDAVNHLDYLGVQVAWISGPWF 519

  Fly   332 LTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLENSAQIFNSLSDIPGEVTD 396
            |::|.|::..:.::|:||...:||:.|
plant   520 LSIFVNIIPWECVLRMWDVLLFEGNRV-------------------------------------- 546

  Fly   397 VEVLFRQALEVGGSLSQTVIDTHRRRHLAYLMADQGHQIGNPEAAPNLPKQQLARRQVRKSKSIL 461
              ||||.|..:.......::.|          .|.|      :|..:|  |.||......|:.:|
plant   547 --VLFRTAFAIMELYGPAIVAT----------KDAG------DAITSL--QSLASSTFDSSQLVL 591

  Fly   462 EAFLFRGDGNEGDQLKNKNIRQTEILVDLREAILKVGRHFITIEPKLAGHIQLTANYSTESHAKD 526
            .|.:.....||....:.:.|.:..:|..:.|.|.| ||    :.....|......::..|....|
plant   592 TACMGYISTNEARLEELRKIHRPAVLEIVEERIQK-GR----VWKDKKGLASKLYSFKHEGSILD 651

  Fly   527 HENFINVARTRKRRAKALHDFERHDDDELG---FRRNDIITIISQKDEHCWVGELNGLRGWFPAK 588
            ||          :::...:|.|..|||:..   |...|...:.|:.|.   :.:|.....|...:
plant   652 HE----------QKSTQRNDGENQDDDDESCSPFLNLDGANVDSEVDS---LPDLQEQVVWMKVE 703

  Fly   589 FVELLDERSKLYTSAG--DDAISETVTDLVRGTLAPAIKAFLEHGMKRPTFLGGPIHPWLYIEEA 651
            ...||:|:......|.  :.|:.|.|.:..|..|:..|:. ||..::.             :::.
plant   704 LCRLLEEKRSAVMRAEELEIALMEMVKEDNRLELSARIEQ-LERDVRE-------------LKQV 754

  Fly   652 ATREVEKDFESVYSRLVLCKTYRLDEDGKV-----LTPEELLYRCVQAINQTHDDAHAQMDVKL 710
            .:.:.|::...:...:.:.:..:|.||.::     ...:......:|..|:......|||:.||
plant   755 LSDKKEQETAMLQVLMKVEQDQKLTEDARINAEQDAAAQRYAVHVLQEKNEKLVTQLAQMEKKL 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	73/255 (29%)
		SH3_SGSM3	540..592	CDD:212747	11/54 (20%)
		RUN	619..773	CDD:280855	15/97 (15%)
AT2G37290	NP_001189697.1	RabGAP-TBC	363..563	CDD:278964	63/244 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22957
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920