DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and GRTP1

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_001273661.1	Gene:	GRTP1 / 79774	HGNCID:	20310	Length:	344	Species:	Homo sapiens

Alignment Length:	289	Identity:	86/289 - (29%)
Similarity:	146/289 - (50%)	Gaps:	28/289 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 RFDEFGFRVEEEDGPEQSSNKLLSIPFVEDAQQRLQWIAHLEFSHNKEAAELSWEHVDVMLPRTE 155
            |.|.:||. ..||..:.:..|..|...|...::.::|...|:...               :||:.
Human    11 RIDPYGFE-RPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGG---------------VPRSR 59

  Fly   156 KLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMTSKQIEKDLLRILPTN 220
            .::..||:|:|...||::||.||||.|:..::...||.:::...|.:|  ...|..||.|..|.|
Human    60 TVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRL--EDAIRTDLNRTFPDN 122

  Fly   221 ACFSNPNGTGIPRLRRILRGIAWLF----PDIGYCQGTGVIVACLLLFM-EEENAFWMMATIVED 280
            ..|..   |..|.|:|.|..:...:    ..:|||||...|...|:|.. .||.:||::..:|..
Human   123 VKFRK---TTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGR 184

  Fly   281 LLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLITLHWFLTLFANVVHMKILV 345
            :|| .|||..:||::.||.|:..|:...|.:|...:.:..:..:|:...||:.||.:::.::.::
Human   185 ILP-DYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETVL 248

  Fly   346 RIWDWFFYEGSIVLFQLTLGMLKVKEQDL 374
            ||||..|.|||.::|::.|.::| :.|:|
Human   249 RIWDCLFNEGSKIIFRVALTLIK-QHQEL 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	73/219 (33%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
GRTP1	NP_001273661.1	TBC	65..278	CDD:214540	73/219 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850