DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and tbc1d2b

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	XP_012822167.2	Gene:	tbc1d2b / 734055	XenbaseID:	XB-GENE-5932742	Length:	944	Species:	Xenopus tropicalis

Alignment Length:	433	Identity:	137/433 - (31%)
Similarity:	215/433 - (49%)	Gaps:	78/433 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 DQPEY---------RFDEFGFRVEEEDGPEQSSNKLLSIPFVEDAQQRLQWIAHLEFSHNKEAAE 141
            :|||:         ::|..||.:..||..|:  .||:       |:.|...:..|..:.|:|.:.
Frog   559 EQPEHTFVKPHTVSKYDIHGFLIVPEDDEEE--EKLV-------AKVRALDLKTLSLTENQEISN 614

  Fly   142 -LSWEH-----VDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETS---YHDIVKA 197
             :.|::     |:..:..:.:|:.:||.||||..|::||...:....||.|.|.:   :..:::.
Frog   615 VVKWDNYFASTVNREMACSPELKALVRNGIPHEHRSRMWKWFTNLHIKKLKDEAAPGYFQSLLQN 679

  Fly   198 SSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLL 262
            :...|...|||||.||:|.||.|..:::|...||.:||.:|...:|..||||||||...:.|..|
Frog   680 ALEKQNPASKQIELDLMRTLPNNKHYTSPTSEGIQKLRNVLLAYSWRNPDIGYCQGINRLAAIAL 744

  Fly   263 LFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLIT 327
            |::::|:|||.:.||||..:|..||:.||||.|.||||...|:...|..:.....::.::.:|||
Frog   745 LYLDQEDAFWCLVTIVEAFMPRDYYTKTLLGSQVDQRVFKDLMNEKLPRLCAHFEQYKVDYTLIT 809

  Fly   328 LHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLENSAQIFNSLSDIPG 392
            .:|||.:|.:.|...||.||||...||||.|:|:..||:.|.||:::..|::|..||..|.
Frog   810 FNWFLVVFVDSVVSDILFRIWDSLLYEGSKVIFRFALGLFKYKEEEILKLQDSMSIFKYLR---- 870

  Fly   393 EVTDVEVLFRQALEVGGSLSQTVIDTHRRRHLAYLMADQGHQIGNPEAAPNLPKQQLARR----- 452
                             ..|:|::|..:..::|::  |.     ||     .|.:|:..|
Frog   871 -----------------YFSRTILDARKLCNIAFV--DM-----NP-----FPLRQIRNRRTYHL 906

  Fly   453 -QVRKSKSILEAFLFRGDGNEGDQLKNKNIRQTEILVDLREAI 494
             :||...|.|||  .|.|          .||:.|...:.|:.|
Frog   907 EKVRLELSELEA--IRAD----------FIRERETNPERRDLI 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	90/216 (42%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
tbc1d2b	XP_012822167.2	PH_TBC1D2A	34..134	CDD:269966
		BAR	313..>425	CDD:416402
		Smc	<324..532	CDD:224117
		TBC	640..857	CDD:214540	90/216 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920