Protein Alignment CG12241 and Tbc1d5

DIOPT Version :9

• Sequence 1: NP_650432.1
• Gene: CG12241 / 41834
• FlyBaseID: FBgn0038304
• Length: 804
• Species: Drosophila melanogaster
• Sequence 2: NP_001272920.1
• Gene: Tbc1d5 / 72238
• MGIID: 1919488
• Length: 837
• Species: Mus musculus
• Alignment Length: 709
• Identity: 127/709 - (17%)
• Similarity: 223/709 - (31%)
• Gaps: 285/709 - (40%)

  Fly   134 SHNKEAAELSWEHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRL-------------SGALAKKQ 185
            |:.||     ||.:.|   ....|..:.::||...||:..:..:             |..::|.:
Mouse    54 SYMKE-----WEELFV---NNNYLATVRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISKIK 110

  Fly   186 KSETSYHDIV--------KASSNDQLMTS---------------------KQIEKDLLRILPTNA 221
            :....|..|.        ||:....||.:                     ..||:|:.|..|...
Mouse   111 ELRAWYSSIKEIHITNPRKAAGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQ 175

  Fly   222 CFSNPNGTGIPRLRRILRGIAWLF----PDIGYCQGTGVIVACLLLFME---------------- 266
            .|...|      :|:||..:.:.:    ..:.|.||...::|.::..:.
Mouse   176 FFQQEN------VRKILTDVLFCYARENEQLLYKQGMHELLAPIIFTLHCDHQAFLHASESAQPS 234

  Fly   267 ------------EENAFWMMATIVEDLLPASYYSSTLLGIQAD-QRVMHTLIA------------ 306
                        |.:|:.|.:.::|...|  ::|:    .:.| |:...||:|
Mouse   235 EEMKTLLNPEYLEHDAYAMFSQLMETAEP--WFST----FEHDGQKGKETLMAPIPFARPQDLGP 293

  Fly   307 --------NYLSSVDESLRKHDIEL-----------SLITLHWFLTLFANVVHMKILVRIWDWFF 352
                    |.:.  |..|:||||||           .:..|.|...||.....::.|:.:||..|
Mouse   294 TVAIVTKVNQIQ--DHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALF 356

  Fly   353 YEG---SIV------------------LFQLTLGML----------------------------- 367
            .:.   |:|                  .:|..||:|
Mouse   357 ADSLNLSLVDYVFTAMLLYIRDALISSNYQTCLGLLMHYPIIGDIHSLILKALFLRDPKRNPRPA 421

  Fly   368 -----------KVKEQDLKHLE---------NSAQIFNSL----------SDIPGEVTDVEVLFR 402
                       |.:..||.:..         |..::.|||          :..||
Mouse   422 TYQFHPNLDYYKARGADLMNKSRTNARGAPLNIHKVSNSLINFGRKLISPASAPG---------- 476

  Fly   403 QALEVGG--------SLSQTVIDTHR-----RRHLAYLMADQGH---QIGNPEAAPNLPKQQLAR 451
               .:||        |.....|.|..     |.||......|.|   |...|:......:||..:
Mouse   477 ---SMGGPVPGNNSSSSFSAAIPTRTSTEAPRHHLLQQQQQQQHQQQQQQQPQQQQQQHQQQQQQ 538

  Fly   452 RQVRKSKSILEAFLFRGDGNEGDQLKNKNIR---QTEILVDLREAILKVGRHFITIEPKLAGHIQ 513
            :::.||:|:....      |:||.:...:.:   ..:.|.||:....|......:|| .|.|..:
Mouse   539 QRLMKSESMPVQL------NKGDVVTGSDAQVSVPVQALTDLQGQSSKTISSSPSIE-SLPGGRE 596

  Fly   514 LTANYSTESHAKDHENFINVARTRKR-RAKALHDFERHDDDELGFRRNDIITIISQKDEHCWVGE 577
            .|.:....:..|| ..|.|:||:|.. :.....:.|...:.::.|.:                |:
Mouse   597 FTGSPPPSATKKD-SFFSNIARSRSHSKTMGRKESEEELEAQISFLQ----------------GQ 644

  Fly   578 LNGLRGW--FPAKFVEL-------------LDERSKLYTS-AGDDAISETVTDLVRGTL 620
            ||.|...  :.||.:::             |::..::..| ||    .:.:.|:::|:|
Mouse   645 LNDLDAMCKYCAKVMDMHLVNIQDVVLQENLEKEDQILVSLAG----LKQIKDILKGSL 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	62/380 (16%)
		SH3_SGSM3	540..592	CDD:212747	8/53 (15%)
		RUN	619..773	CDD:280855	1/2 (50%)
Tbc1d5	NP_001272920.1	TBC	79..381	CDD:214540	54/315 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900