DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and Tbc1d10b

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_653105.3	Gene:	Tbc1d10b / 68449	MGIID:	1915699	Length:	798	Species:	Mus musculus

Alignment Length:	489	Identity:	126/489 - (25%)
Similarity:	205/489 - (41%)	Gaps:	101/489 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EHTRKLQNLGSEDDL--------GELPPMMEELSVADGLRPNPGGPFSALTASMWPQEILAKLGG 76
            |.....|:|||...|        |:.|   :.||..|.:....|      |....|.:: :.:|.
Mouse   224 EPVENFQDLGSTSSLGPGISGPRGQAP---DTLSYLDSVSLMSG------TLESLPDDV-SSMGS 278

  Fly    77 GAELASGPNDQPEYRFDEFGFRVEEEDGPEQSSNKLLSIPFVEDAQQR-LQWIAHLEFSHNKEAA 140
            .:|:    |.....:.|::||.    .|.:.|.:...||| |:.|:|| |:|   ||...|.:
Mouse   279 DSEI----NGMALRKTDKYGFL----GGSQYSGSLESSIP-VDVARQRELKW---LEMFSNWD-- 329

  Fly   141 ELSWEHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMT 205
              .|     :..|.:|::...|:|||.:|||:.|..||.:....:::...:.::.:|:.:.:.:
Mouse   330 --KW-----LSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAAGDPKWL- 386

  Fly   206 SKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEENA 270
             ..|||||.|..|.:..|:...|.|...|.|||:......||.||||....:.|.||:.|..|.|
Mouse   387 -DVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQA 450

  Fly   271 FWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLITLHWFLTLF 335
            ||.:..|.:..|| .|||:.|..||.|..:...|:..........||:..|:..|....||:.:|
Mouse   451 FWCLVQICDKYLP-GYYSAGLEAIQLDGEIFFALLRRVSPLAHRHLRRQRIDPVLYMTEWFMCIF 514

  Fly   336 ANVVHMKILVRIWDWFFYEGSIVLFQLTL-----------------GMLKVKEQDLKHLENSAQ- 382
            |..:....::|:||.||.||..::|::.|                 ||.:..|| |::|.....
Mouse   515 ARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQ-LRNLPQQCMQ 578

  Fly   383 ---IFNSLSDIPGEVTDV------------------EVLFRQALEVGGSLSQTVIDTHRRRHLAY 426
               :.:.::::|  ||:.                  |:.:|.:..:.||   ..|...|||.
Mouse   579 EDFLVHEVTNLP--VTEAWIERENAAQLKKWRETRGELQYRPSRRLHGS---RAIHEERRRQ--- 635

  Fly   427 LMADQGHQIGNPEAAPNLPKQQLARRQVRKSKSI 460
                      .|...|:.....|...:.|.|:::
Mouse   636 ----------QPPLGPSSSLLSLPSLKSRGSRAV 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	71/230 (31%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
Tbc1d10b	NP_653105.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..79
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..211
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..250		6/24 (25%)
		TBC	343..548	CDD:214540	67/207 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..798		11/58 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840