DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and Tbc1d8

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	XP_006244913.1	Gene:	Tbc1d8 / 680133	RGDID:	1595491	Length:	1150	Species:	Rattus norvegicus

Alignment Length:	802	Identity:	194/802 - (24%)
Similarity:	308/802 - (38%)	Gaps:	218/802 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GGAELASGPNDQPEYRFDEFGFRVEEEDGPEQSSNKLLSIPFVEDAQQ----RLQWIAHLEFSHN 136
            |..|:.|..:.:..          |:|..|......|.:: |.:...|    ||          :
  Rat   442 GDLEMVSSQSSEER----------EKEKSPLPHPEPLTAV-FQQSGSQSPDSRL----------S 485

  Fly   137 KEAAELS-W-EHV-----DVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDI 194
            :|..::| | :|.     .|.:.||||:|.:|..|||.:||.::|:..|.|:.........|.::
  Rat   486 REQIKISLWNDHFAEYGRTVCMFRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNL 550

  Fly   195 VKASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVA 259
            |:.|.....:.:::||:||.|.||.:..|.|.  |||..|||:|...|...|.|||||...::.:
  Rat   551 VEQSLGRCCLVTEEIERDLHRSLPEHPAFQNE--TGIAALRRVLTAYAHRNPKIGYCQSMNILTS 613

  Fly   260 CLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIE-L 323
            .|||:.:||.|||::..:.|.:|| .|::..::|.|.||.|...||..:|..:.|.:  .|:. |
  Rat   614 VLLLYAKEEEAFWLLVAVCERMLP-DYFNHRVIGAQVDQSVFEELIKEHLPELAEHM--SDLSAL 675

  Fly   324 SLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQD--------------- 373
            :.|:|.||||||.:::.::..|.:.|.|||:|...:|||.|.:|:...::
  Rat   676 ASISLSWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAEELCSSKDDGQALMILS 740

  Fly   374 --LKHLEN---------SAQIFNSLSDIPGEVTDVEVLFRQALEVGGSLSQTVIDTHRRRHLAYL 427
              |.|::|         |...|.|....|..|||:..|.|.:.|..|:.|...|:..|.:|...:
  Rat   741 RFLDHIKNEDSPGPPIGSHHAFFSDDQEPCPVTDIADLIRDSYEKFGNQSVEQIEHLRCKHRIRV 805

  Fly   428 MADQGHQIGNPEAAPNLPKQQLARRQVRKSKSILEAFLFRGDGNEGDQLKNKNIRQTEILVDLRE 492
            :  |||:        :..||.:. |.|....|||...|                   |.|.||.:
  Rat   806 L--QGHE--------DTTKQNVL-RVVIPEVSILPEDL-------------------EELYDLFK 840

  Fly   493 AILKVGRHFITIEPKLAGHIQLTANYSTESHAKDHENFINVARTRKRRAKALHDFERHDDDELGF 557
                            ..|:.   |...|.|                |..||    |||......
  Rat   841 ----------------RAHMM---NCYWEHH----------------RPIAL----RHDPSRPYA 866

  Fly   558 RRNDIITIISQKDEHCWVGELNGL-RGWFPAKFVELLDER--------------SKLYTSAGD-- 605
            .:..|        :.|....|..| ..|......|:|.||              .|.:.|..|
  Rat   867 EQYRI--------DACQFAHLFQLVSPWTCGAHTEILAERIFRLLDDNMDQLIEFKAFVSCLDVM 923

  Fly   606 --DAISETVTDLVRGTLAPAI-------KAFLEHGM---KRPTFLGGPIHPWLYIEEAATREVEK 658
              ..:||.:..|.|..:.||:       ::.|::.:   .||..||.|        ...|.:.:|
  Rat   924 YNGEMSEKIKLLYRLHIPPALTENDRDSQSPLKNPLLSTSRPLVLGRP--------NGDTIDYQK 980

  Fly   659 DFESVYSRLVLCKTYRLDEDGKVLTPEELLYRCVQAINQTHDDAHAQMDVKLRSLICLGLNEQVL 723
            ..:.:...|...|. :::::...::..|.:..|....:..|:|.. :.|:           .|.:
  Rat   981 QLKQMIKDLAKEKD-KMEKELPKMSQREFIQFCKTLYSMFHEDPE-ENDL-----------YQAI 1032

  Fly   724 HLWLEVLCACQEVVQKWYHSWSFIDSPGWVQIKCELRILSQFAFNLNPDWELPPKR-------GK 781
            .....:|....||.|:.       .|.|....:||           .|....||::       ||
  Rat  1033 ATVTTLLLQIGEVGQRG-------SSSGSCSQECE-----------EPQASAPPEQDSVFAEAGK 1079

  Fly   782 ESQ--PLKDGVRDMLVKHHLFS 801
            ..|  |..:|...:.::|.|.|
  Rat  1080 SPQAFPETEGDWTVSLEHILAS 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	77/231 (33%)
		SH3_SGSM3	540..592	CDD:212747	11/52 (21%)
		RUN	619..773	CDD:280855	27/163 (17%)
Tbc1d8	XP_006244913.1	PH-GRAM1_TBC1D8	171..269	CDD:270156
		PH-GRAM2_TBC1D8	311..406	CDD:270160
		TBC	520..726	CDD:214540	76/210 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810