DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and tbc1d8b

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	XP_009299628.1	Gene:	tbc1d8b / 566657	ZFINID:	ZDB-GENE-030131-3135	Length:	1152	Species:	Danio rerio

Alignment Length:	704	Identity:	166/704 - (23%)
Similarity:	270/704 - (38%)	Gaps:	210/704 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 DEFGFRVEEEDGPEQ--SSNKLLSIPFVEDAQQRLQWIAHLEFSHNKE-AAELSWEHVDVMLPR- 153
            ||.|..|    |..|  |:..|:::....||:       :|:....|| ..|.||:.......|
Zfish   400 DEEGVMV----GQSQAVSTEALMNVFHPHDAE-------NLDPKMLKERMKEQSWQIHFAEYGRG 453

  Fly   154 -----TEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMTSKQIEKDL 213
                 |:|.|:::.:|:|.|||.::||..|||:.........|..:::.......:...:||:||
Zfish   454 TGMFCTKKTRDLIVRGVPETLRGELWMLFSGAVHDMISHPGYYGRLLEDCMGSSSLACDEIERDL 518

  Fly   214 LRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATIV 278
            .|.||.:..|.  :.|||..|||:|...|...|.|||||...::.:.|||:.:||.|||::..:.
Zfish   519 HRSLPEHPAFQ--SDTGISALRRVLTAYAHRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVC 581

  Fly   279 EDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSL---ITLHWFLTLFANVVH 340
            |.:|| .|::..::|...||.|...||..:|:.:.|    |..:||.   ::|.||||||.:|:.
Zfish   582 ERMLP-DYFNRRIIGALVDQAVFEELIREHLTQLTE----HMTDLSFFSSVSLSWFLTLFISVLP 641

  Fly   341 MKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLENSAQ-----------IFNSLSDIPGEV 394
            ::..|.:.|.|||:|...:.||.|.:|.....:|....:.|:           :.|..|.:|..|
Zfish   642 IESAVNVVDCFFYDGIKAILQLGLAVLDYNMDNLLCCNDDAEAVTVLNRFFDSVTNKDSPLPATV 706

  Fly   395 --------------TDVEVLFRQALEVGGSLSQTVIDTHRRRHLAYLMADQGHQIGNPEAAPNLP 445
                          .|:..|.::|.|..|.:....::..|:|:..|::          :...:..
Zfish   707 QQASATANDKSIQKVDISDLIKEAYEKYGDIRTEEVENMRKRNKLYVI----------QTLEDTT 761

  Fly   446 KQQLAR---RQVRKSKSILEA--FLFRGDGNEGDQLKNKNIRQTEILVDLREAILKVGRHFI--- 502
            ||.:.|   :.|:.|.|.|:.  .||:              ||                ||:
Zfish   762 KQNVLRVVAQDVKFSASQLDELYLLFK--------------RQ----------------HFVCCY 796

  Fly   503 --TIEPKLAGH--------------------IQLTANYSTESHAKDHENFINVARTRKRRAKALH 545
              ...|.|..|                    ..|...::|.:|::      ::||:      |.|
Zfish   797 WSVCSPALQNHDPSLPYLDQYQLDQSQFSSLFNLLQPWTTHTHSR------SLARS------AFH 849

  Fly   546 DFERHDDDELGFRRNDIITIISQKDEHCWVGELNGLRGWFPAKFVELLDERSKLYTSAGDD---- 606
            ..:.:.|..:.|           |:..|      ||...:...|.|.|....||:...|:.
Zfish   850 LLDENGDGLVNF-----------KEFIC------GLDILYNRSFTEKLKLLFKLHLQPGNQECKI 897

  Fly   607 -----------------AISETVTDLV------RGTLAPAIKAFLEHGMKRPTFLGGPIHPWLYI 648
                             .:|::..|.|      ||.....::.:|:.              |.
Zfish   898 LPSSRFFPPGEDHSFSTRLSDSAEDGVIRKCPERGRAKVDLQEYLKQ--------------WQ-- 946

  Fly   649 EEAATREVE-KDFESV--YSRLVLCKT----YRLDEDGKVLTPEELLYRCVQAI 695
            |:...||.. ||...:  ...:.|.||    :..||:      ||.|||.|..:
Zfish   947 EDLQRREENIKDLPRINQVQFISLTKTLYSVFHGDEE------EESLYRAVARV 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	74/216 (34%)
		SH3_SGSM3	540..592	CDD:212747	9/51 (18%)
		RUN	619..773	CDD:280855	18/84 (21%)
tbc1d8b	XP_009299628.1	PH-like	154..252	CDD:302622
		PH-GRAM2_TBC1D8B	294..386	CDD:270159
		TBC	468..676	CDD:214540	74/214 (35%)
		EF-hand_7	<819..866	CDD:290234	10/69 (14%)
		Vert_HS_TF	1033..>1150	CDD:284062
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940