DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and rabgap1l

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	XP_021325262.1	Gene:	rabgap1l / 555272	ZFINID:	ZDB-GENE-050208-389	Length:	1069	Species:	Danio rerio

Alignment Length:	785	Identity:	158/785 - (20%)
Similarity:	283/785 - (36%)	Gaps:	224/785 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GSEDDLGELPPMMEEL----------SVADGLRPNPGGPFSALTASMWPQEILAKLGGGAELASG 83
            ||:||      ||.|:          |.|.|...:|       |....|:|     ...:|::||
Zfish   475 GSQDD------MMYEVVSLEKHSECGSQARGRLQSP-------TEEEEPEE-----DSDSEISSG 521

  Fly    84 PNDQPEYRFDEFGFRVEEEDGPEQSSNKLLSIPFVEDAQQRLQWIAHLEFSHNKEAAELSWEHVD 148
            ..|             ..:|.||    |:|.           .|...|.          .|:  .
Zfish   522 TGD-------------VSKDCPE----KILE-----------SWGGILN----------RWQ--G 546

  Fly   149 VMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMTSKQIEKDL 213
            .:|.|.:.|..:|:.|||..|||::|..|||....:...|.....|.|.|:.:.::|     :|:
Zfish   547 NLLTRPKGLSALVKPGIPEALRAEVWQLLSGCHNDQALLEQYRILITKESAQEAVIT-----RDI 606

  Fly   214 LRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATIV 278
            .|..|.:..|.:..|.|...|.:|.:..:....:||||||...:.|.|||.|.||.||.::..|:
Zfish   607 HRTFPAHDYFKDSGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIM 671

  Fly   279 EDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLITLHWFLTLFANVVHMKI 343
            .:......|.:....:......:..|:...|..:....::.::|..:....||||||.....:.:
Zfish   672 FNYGLRELYRNNFEDLHCKFYQLERLLQELLPDLWSHFQELNLEAHMYASQWFLTLFTAKFPLCM 736

  Fly   344 LVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLENSAQIFNSLSDIPGEVTDVEVLFRQALEVG 408
            :..|.|....||..::|.:.|.:||..::||..                  .|.|
Zfish   737 VFHITDLLLCEGLNIIFNVALALLKTSKEDLLQ------------------ADFE---------- 773

  Fly   409 GSLSQTVIDTHRRRHLAYLMADQGHQIGNPEAAPNLPKQQLARRQVRKSKSILEAFLFRGDGNEG 473
            |:|....:...:|    |..|:...::........:|.::|.:.: ::.:|:.|:.|.:.|..:.
Zfish   774 GALKFFRVQLPKR----YRAAENARRLMEQACNIKVPTKKLKKFE-KEYQSLRESQLQQEDPIDR 833

  Fly   474 DQLKNKNIRQTEILVDLREAILKVGRHFITIEPKLAGHIQLTANYSTESHAKDHENFIN--VART 536
            .|.:|:.:::..:.::.....|  ....:|.:..|...:         ..|:|..:.:|  :..|
Zfish   834 YQRENRRLQEASMRLEQENDDL--AHELVTSKIALRNDL---------DQAEDKADVLNKELLNT 887

  Fly   537 RKRRAKALHDFERHDDDELG----FRRNDIITIISQKDEHCWVGELNGLRGWFPAKFVELLDERS 597
            ::|..:...:..|.:::...    |||.      .:|.|.    |:.        |...::.|..
Zfish   888 KQRLVETEEEKRRQEEETAQLKEVFRRE------LEKAEQ----EIK--------KTTAIIAEYK 934

  Fly   598 KLYTSAGDDAISETVTDLVRGTLAPAIKAFLEHGMKRPTFLGGPIHPWLYIEEAATREVEKDFES 662
            ::        .|:..|.|.:                               ::|:|:|   :.:.
Zfish   935 QI--------CSQLSTRLEK-------------------------------QQASTKE---ELDI 957

  Fly   663 VYSRLVLCKTYR--LDEDGKVLTPEELLYRCVQAINQTH-----DDAHAQMDVKLRSLICLGLNE 720
            |.::::.|:..|  ..:||.:..|         .::|.:     |:....:..:||.|. |.|.:
Zfish   958 VKAKVMACERCREVFSKDGPLQIP---------PVSQDNRDTDLDEEKDSLKAQLRELE-LELAQ 1012

  Fly   721 QVLHLWLEVLCACQEV----------VQKWYHSWSFIDSPGWVQIKCELRILSQFAFNLNPDWEL 775
            ..|.| :|..|..||:          ||...:||          ....|..|...|.|.:|.
Zfish  1013 TKLQL-VEAKCKIQELEHQRGVLMTEVQAAKNSW----------FSKTLGSLKNSASNQSPS--- 1063

  Fly   776 PPKRG 780
            .||.|
Zfish  1064 SPKEG 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	59/213 (28%)
		SH3_SGSM3	540..592	CDD:212747	8/55 (15%)
		RUN	619..773	CDD:280855	31/170 (18%)
rabgap1l	XP_021325262.1	PTB_Rab6GAP	157..285	CDD:269922
		DUF3694	319..450	CDD:315198
		RabGAP-TBC	565..768	CDD:306939	55/207 (27%)
		SMC_N	784..>1042	CDD:330553	55/344 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810