DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and Tbc1d8

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	XP_017177250.1	Gene:	Tbc1d8 / 54610	MGIID:	1927225	Length:	1160	Species:	Mus musculus

Alignment Length:	809	Identity:	191/809 - (23%)
Similarity:	309/809 - (38%)	Gaps:	236/809 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 DEFG--FRVEEEDGPEQSSNKLLSIP------FVEDAQQ----RLQWIAHLEFSHNKEAAELS-W 144
            |:||  ..|..:...|:...:.|..|      |.:...|    ||          ::|..::| |
Mouse   439 DKFGDLEMVASQSSEEREEKRPLPHPEPLTAVFQQSGSQSPDSRL----------SREQIKISLW 493

  Fly   145 -EHV-----DVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQL 203
             :|.     .|.:.||||:|.:|..|||.:||.::|:..|.|:.........|.::|:.|.....
Mouse   494 NDHFVEYGRTVCMFRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEQSLGRCC 558

  Fly   204 MTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEE 268
            :.:::||:||.|.||.:..|.|.  |||..|||:|...|...|.|||||...::.:.|||:.:||
Mouse   559 LVTEEIERDLHRSLPEHPAFQNE--TGIAALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYAKEE 621

  Fly   269 NAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIE-LSLITLHWFL 332
            .|||::..:.|.:|| .|::..::|.|.||.|...||...|..:.|.:  .|:. |:.|:|.|||
Mouse   622 EAFWLLVAVCERMLP-DYFNHRVIGAQVDQSVFEELIKEQLPELAEHM--SDLSALASISLSWFL 683

  Fly   333 TLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQD-----------------LKHLEN- 379
            |||.:::.::..|.:.|.|||:|...:|||.|.:|:...::                 |.|::|
Mouse   684 TLFLSIMPLESAVHVVDCFFYDGIKAIFQLGLAVLEANAEELCSSKDDGQALMVLSRFLDHIKNE 748

  Fly   380 --------SAQIFNSLSDIPGEVTDVEVLFRQALEVG-----------GSLSQTVIDTHRRRHLA 425
                    |...|.|....|..|||:..|.|.:.|:.           |:.|...|:..|.:|..
Mouse   749 DSPGPPIGSHHAFFSDDQEPYPVTDIADLIRDSYELWTQAVPVSMQKFGNQSVEQIEHLRCKHRI 813

  Fly   426 YLMADQGHQIGNPEAAPNLPKQQLARRQVRKSKSILEAFLFRGDGNEGDQLKNKNIRQTEILVDL 490
            .::  |||:        :..||.:. |.|....|||...|                   |.|.||
Mouse   814 RVL--QGHE--------DTTKQNVL-RVVIPEVSILPEDL-------------------EELYDL 848

  Fly   491 REAILKVGRHFITIEPKLAGHIQLTANYSTESHAKDHENFINVARTRKRRAKAL-HD-----FER 549
            .:....:..::                   |.|                |..|| ||     .|:
Mouse   849 FKRAHMMSCYW-------------------EHH----------------RPMALRHDPSRPYAEQ 878

  Fly   550 HDDDELGFRRNDIITIISQKDEHCWVGELNGLRGWFPAKFVELLDER--------------SKLY 600
            :..|...|..  :..::|.               |......|:|.||              .|.:
Mouse   879 YRIDARQFAH--LFQLVSP---------------WTCGVHTEILAERLFRLLDDNMDQLIEFKAF 926

  Fly   601 TSAGD----DAISETVTDLVRGTLAPAI-------KAFLEHGM---KRPTFLGGPIHPWLYIEEA 651
            ||..|    ..::|.:..|.|..:.||:       ::.|::.:   .||..||.|        ..
Mouse   927 TSCLDIMYNGEMNEKIKLLYRLHIPPALTENDRDSQSPLKNPLLSTSRPLVLGKP--------NG 983

  Fly   652 ATREVEKDFESVYSRLVLCKTYRLDEDGKVLTPEELLYRCVQAINQTHDDAHAQMDVKLRSLICL 716
            .|.:.:|..:.:...|...|. :::::...::..|.:..|....:..|:|.. :.|:
Mouse   984 DTIDYQKQLKQMIKDLAKEKD-KMEKELPKMSQREFIQFCKTLYSMFHEDPE-ENDL-------- 1038

  Fly   717 GLNEQVLHLWLEVLCACQEVVQKWYHSWSFIDSPGWVQIKCELRILSQFAFNLNPDWELPPKR-- 779
               .|.:.....:|....||.|:.       .|.|....:||           .|....||::
Mouse  1039 ---YQAIATVTTLLLQIGEVGQRG-------SSSGSCSQECE-----------EPQASAPPEQDS 1082

  Fly   780 -----GKESQ--PLKDGVRDMLVKHHLFS 801
                 ||..|  |..:|...:.::|.|.|
Mouse  1083 VFAEAGKSPQAFPETEGDWTVSLEHILAS 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	77/231 (33%)
		SH3_SGSM3	540..592	CDD:212747	10/57 (18%)
		RUN	619..773	CDD:280855	27/163 (17%)
Tbc1d8	XP_017177250.1	PH-GRAM1_TBC1D8	171..269	CDD:270156
		PH-GRAM2_TBC1D8	311..406	CDD:270160
		TBC	519..725	CDD:214540	76/210 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840