Protein Alignment CG12241 and TBC1D25

DIOPT Version :9

• Sequence 1: NP_650432.1
• Gene: CG12241 / 41834
• FlyBaseID: FBgn0038304
• Length: 804
• Species: Drosophila melanogaster
• Sequence 2: NP_001335191.1
• Gene: TBC1D25 / 4943
• HGNCID: 8092
• Length: 704
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 108/517 - (20%)
• Similarity: 173/517 - (33%)
• Gaps: 183/517 - (35%)

  Fly     4 ARSIFGRDHEG--YVGREEHTRKLQNLGSEDDLGELPPMMEELSVADG------------LRPNP 54
            |..:.|:.:.|  |:||:       .||.|..|..|...  :||.|..            :||:.
Human    89 AFDLSGKKNFGISYLGRD-------RLGQEVYLSLLSDW--DLSTAFATASKPYLQLRVDIRPSE 144

  Fly    55 GGPFSALTASMWPQEILAKLGGGAELASGPNDQPEYRFDEFGFRVEEEDGPEQSSNKLLSIPFVE 119
            ..|.......:.|:::   :|....||.                       ::||....::||.:
Human   145 DSPLLEDWDIISPKDV---IGSDVLLAE-----------------------KRSSLTTAALPFTQ 183

  Fly   120 D-----------AQQRLQW------------IAHLEFSHNKEAAELSWEHVDVMLPRTEKLR-NM 160
            .           .||.|.|            ::..||.        ::.:.:..|.|.|:|| .:
Human   184 SILTQVGRTLSKVQQVLSWSYGEDVKPFKPPLSDAEFH--------TYLNHEGQLSRPEELRLRI 240

  Fly   161 VRQGIPHTLRAQMWMRL-----SGALAK------KQKSETSYHDI-----VKASSNDQLMTSKQI 209
            ...|:..:||..:|..|     .|...:      |:||. .|..:     .:|:..|.......:
Human   241 YHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSR-EYEQLKSEWAQRANPEDLEFIRSTV 304

  Fly   210 EKDLLRILPTNACFSNP-NGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEE-NAFW 272
            .||:||....:..::.| :|..:..|..:|...|...|.:.||||...:.:.:|..|:.| :||.
Human   305 LKDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFV 369

  Fly   273 MMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLITLHWFLTLFAN 337
            ....|:: .|.|:::        .|.|.|.|..|
Human   370 CFCGIMK-RLAANFH--------PDGRAMATKFA------------------------------- 394

  Fly   338 VVHMKILVRIWDWFFYE-----GSIVLF--------QL--------TLGMLKVKEQDLKHLENSA 381
              |:|:|:|..|..||:     |:..||        :|        .|.||:|....|.......
Human   395 --HLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEH 457

  Fly   382 QIFNSLSDIPGEVTDV--------EVLFRQALEV---GGSLSQTVIDTHRRRHLAYLMADQG 432
            ::  .|...|.:|.|.        .|..|..|..   |||..:..:|     |||  .|.||
Human   458 EV--ELVGPPSQVADAGFGGHRGWPVRQRHMLRPAGGGGSTFEDAVD-----HLA--TASQG 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	54/252 (21%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
TBC1D25	NP_001335191.1	TBC	241..470	CDD:214540	58/273 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810