DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and tbc1d15

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	XP_005159143.1	Gene:	tbc1d15 / 492676	ZFINID:	ZDB-GENE-041111-251	Length:	665	Species:	Danio rerio

Alignment Length:	445	Identity:	92/445 - (20%)
Similarity:	161/445 - (36%)	Gaps:	107/445 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 LGGGAELASGPNDQPEYRFDEFGFRVEEEDGPEQSSNKLLS-----IPFVEDAQQR---LQWIAH 130
            |||.:::.:       |.||  .||..|.:..::.:.::..     ||.:|..||.   .:.|..
Zfish   226 LGGFSKVTN-------YLFD--AFRAPELECQQRPAEEVADVLGELIPGLEINQQEEPGFEVITR 281

  Fly   131 LEFSHNKEAAEL------SWEHVDVMLPRTEKLRNM----VRQGIPHTLRAQMWMRLSG------ 179
            |:.....|....      .|.....:..|...|.::    .:.|:.|.:|.:.|..|.|
Zfish   282 LDLGPRPEMQRTGPVTMEEWAKYQDLEGRMTNLPHLKDAIFKGGLCHAVRKEAWKFLLGYFPWSS 346

  Fly   180 -----ALAKKQKSETSYHDIV--KASSNDQLMTSKQ-------IEKDLLRILPTNACFSNPNGTG 230
                 .|.:|:|::..:...:  |:.|.:|...:.:       ||||:.|....|..:...:..|
Zfish   347 THEERKLLQKRKTDEYFRMKLQWKSVSEEQERRNSRLRDYRSLIEKDVNRTDRNNKFYEGLDNPG 411

  Fly   231 IPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEE-NAFWMMATIVEDLLPASYYSSTLLGI 294
            :..|..||........|:||.||...:::.:|..||.| :|||...:.::::  ...:...:.|:
Zfish   412 LILLHDILMTYCMYDFDLGYVQGMSDLLSPILFVMENEVDAFWCFVSFMDEM--HENFEEQMQGM 474

  Fly   295 QADQRVMHTLIA-------NYLSSVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWDWFF 352
            :.....:.||:.       |||.:.|..       .......|.|..|...:|.:.::|:|:..:
Zfish   475 KTQLIQLSTLLRLLDLAFWNYLEAQDSG-------YLYFCFRWLLIRFKRELHFQDVLRLWEVMW 532

  Fly   353 YEGSIVLFQL-----TLGMLKVKEQD--------LKHL----------------ENSAQIFNSLS 388
            .......|.|     .|...|.|..|        |||:                |:......|..
Zfish   533 TRLPCQNFHLLVCCAILDSEKQKIMDRKYGFNEILKHINELSMKLDIEEILSKSESICMQIKSCK 597

  Fly   389 DIPGEVTDVEVLF-----RQALEVG--GSLSQ---TVIDTHRRRHLAYLMADQGH 433
            |:|..|:::..|.     ..|||..  |.|..   :...:||:.|    :...||
Zfish   598 DLPHSVSEILGLNTVSEPSAALETSEYGILESPQTSPRSSHRQDH----VVSNGH 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	53/254 (21%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
tbc1d15	XP_005159143.1	DUF3548	4..220	CDD:192931
tbc1d15	XP_005159143.1	TBC	322..557	CDD:214540	52/243 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900