DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and CG42795

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_001287272.1	Gene:	CG42795 / 41252	FlyBaseID:	FBgn0261928	Length:	3213	Species:	Drosophila melanogaster

Alignment Length:	394	Identity:	95/394 - (24%)
Similarity:	172/394 - (43%)	Gaps:	69/394 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 WEHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKK------QKSETSYHDIVKASSNDQ 202
            |.|...::.|       :..|.|...|.::|:.|:....|.      |:.|..:   .:....|.
  Fly   208 WLHAMKLVAR-------LPGGTPPEFRRKLWLSLADKYLKSKNVDWAQQREKCF---CEEWREDD 262

  Fly   203 LMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFM-- 265
            .....||.|||.| ..:|.|..........:|:|||.|.|...|::|||||..::.|.:|..|
  Fly   263 EELGIQIVKDLHR-TGSNLCTGPAGSINQAKLKRILLGYARYNPEVGYCQGFNMLGALILQVMDK 326

  Fly   266 EEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRK--HDIE------ 322
            |||.:..:|..:||.:||..|:..::.|:|||..|...|:...|..:.:.|::  ..:|
  Fly   327 EEEESMKVMIYLVEGVLPTGYFYGSMGGLQADMGVFRELMQTRLPRLAKHLQRLQGPVENAFEPP 391

  Fly   323 -LSLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLENSAQIFNS 386
             .::.|:.||||:|...:.|..::|:||....|||.||.:..|.:..:.|:.:..:.::.:.:..
  Fly   392 LTNVFTMQWFLTMFCTCLPMSCVLRVWDLVLIEGSDVLLRTALVLWSLLEERVISVRSADEFYGK 456

  Fly   387 LSD-----IPGEVTDVEVLFRQALEVG--GSLSQTVIDTHRRRHL---AYLMADQGHQIGNPEAA 441
            :..     :.|.:.|...|..:.:::|  ..|.|.     |.:||   |.|...||.|:...|..
  Fly   457 MGSYSSELLNGHLVDSNGLIERVVKLGPIEDLRQL-----RDKHLYNIAPLRHKQGLQLYYDEED 516

  Fly   442 PNLPKQQLA---------------------RRQV-RKSKSILEAFLFRGDGNEGDQLKNKNIRQT 484
            .:..:::||                     ::|| :|.:..|:..|.:   .:.|:|:.:. :|.
  Fly   517 THSDEERLAVATVFGLNWGRRGSVGPAAAGKQQVEQKDRLALDISLLK---KQYDRLRERQ-KQA 577

  Fly   485 EILV 488
            .:::
  Fly   578 HVIL 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	67/230 (29%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:278964	58/175 (33%)
		DUF4682	560..684	CDD:292361	4/26 (15%)
		DBP	1112..1415	CDD:289157
		SWIRM-assoc_2	<2376..2482	CDD:293105
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456600
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.750