DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and plx

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_001163511.1	Gene:	plx / 40704	FlyBaseID:	FBgn0261261	Length:	1572	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	121/544 - (22%)
Similarity:	218/544 - (40%)	Gaps:	118/544 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 RVEEEDG---PEQSSNKL--LSIPFVE----DAQQRLQWIAHLEFSH----NKEAAELSWEHVDV 149
            |:|.|:.   ..|:.|:|  :.:.:.|    |.|...:|...:|.:.    ||:..::
  Fly   871 RMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKV------- 928

  Fly   150 MLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKS--------------ETSYHDIVKASSN 200
                   |.:.:|.|:|.:.|..:|..|:     :|.|              .|.||.::|..:.
  Fly   929 -------LGHAIRTGVPRSKRGDVWTFLA-----EQHSMNTAPVDTKRFPNFNTPYHMLLKHLTE 981

  Fly   201 DQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFM 265
            .|    ..|..||.|..|.:..:.:|.|.|...|..:|:..:.|.|::|||||.|.|...|||..
  Fly   982 HQ----HAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHC 1042

  Fly   266 EEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLITLHW 330
            :|.|:|.::..::......:.|...:...|.....:..|:.::|..:...|.::|:..:|....|
  Fly  1043 DEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPW 1107

  Fly   331 FLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLENSAQIFNSLSDI--PGE 393
            .||:|::...:..:.|::|..|.|.|.|:|:..:.:|.|.:|.|...:|..:|.:.|..:  ..|
  Fly  1108 ILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKME 1172

  Fly   394 VTDVEVLFRQ--ALEVGGSLSQTVID--------THRRRHLAYLMADQGHQIGNPEAAPNLPKQQ 448
            .|.:|.:.:.  ::::|..|::..::        |....||..|         |.|...|    |
  Fly  1173 HTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTTNHHLEML---------NREKTQN----Q 1224

  Fly   449 LARRQVRKSKSILEAFLFRGDGNEGDQLKNKNIRQTEILVDLREAILKVGRHFITIEPKLAGHIQ 513
            ...:|::.::|.:.            ||:.....|...:..|:..:           ..|...||
  Fly  1225 HLEQQLQFAQSSIA------------QLETTRSSQQAQITTLQSQV-----------QSLELTIQ 1266

  Fly   514 LTANYSTESHAKDHENFINVARTRKRRAKALHDFERHDDDELGFRRNDIITIISQKDEHCWVGE- 577
            ....|  .....:|...:.:....:|..:.|.|.:|.       ||..|.|  .:|     :|:
  Fly  1267 TLGRY--VGQLVEHNPDLELPNEVRRMLQQLDDLDRQ-------RRKPIFT--ERK-----IGKS 1315

  Fly   578 --LNGLRGWFPAKFVELLDERSKL 599
              :|...| ||.|.:|.|.||.:|
  Fly  1316 VSVNSHLG-FPLKVLEELTERDEL 1338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	59/227 (26%)
		SH3_SGSM3	540..592	CDD:212747	14/54 (26%)
		RUN	619..773	CDD:280855
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	835..880	CDD:288663	3/8 (38%)
		TBC	933..1152	CDD:214540	59/227 (26%)
		RILP-like	<1176..1267	CDD:304877	19/126 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940