DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and sgsm3

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_998495.1	Gene:	sgsm3 / 406635	ZFINID:	ZDB-GENE-040426-2635	Length:	755	Species:	Danio rerio

Alignment Length:	757	Identity:	474/757 - (62%)
Similarity:	591/757 - (78%)	Gaps:	14/757 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PNPGGPFSALTASMWPQEILAKLGGGAELASGPNDQPEYRFDEFGFRVEEEDGPEQSSNKLL--- 113
            |.|||||||||.|||||:||||.     ....|..:.|.::||||||::.|||.|  :.|.|
Zfish     7 PAPGGPFSALTPSMWPQDILAKY-----CQKDPGTEVELQYDEFGFRIDSEDGVE--TRKWLCGD 64

  Fly   114 SIPFVEDAQQRLQWIAHLEFSHNKEAAELSWEHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLS 178
            ..|..||.||||:|.|||||:||....:|:|:.:...|.|:::||::|..||||::|.|:|||||
Zfish    65 GAPQREDPQQRLRWQAHLEFTHNHTVGDLTWDKITPTLARSDRLRSLVLGGIPHSMRPQLWMRLS 129

  Fly   179 GALAKKQKSETSYHDIVKASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAW 243
            |||.||:.|:.||.:|||.||||....:|||||||||.:||||||:.....|:|:|||:|||:||
Zfish   130 GALQKKRTSDISYREIVKNSSNDDTTAAKQIEKDLLRTMPTNACFNTLTSVGVPKLRRVLRGLAW 194

  Fly   244 LFPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANY 308
            |:||||||||||::|:|||||:|||:|.|||..::|||||.||:||||||:|.||||:..||..|
Zfish   195 LYPDIGYCQGTGMVVSCLLLFLEEEDALWMMCALIEDLLPPSYFSSTLLGVQTDQRVLRQLIVQY 259

  Fly   309 LSSVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQD 373
            |..:|:.|::|||||||||||||||.||:||.::||:||||..|||||:||||:||||||:||.:
Zfish   260 LPRLDKLLQEHDIELSLITLHWFLTAFASVVDIRILLRIWDLLFYEGSMVLFQVTLGMLKIKEDE 324

  Fly   374 LKHLENSAQIFNSLSDIPGEVTDVEVLFRQALEVGGSLSQTVIDTHRRRHLAYLMADQGHQIGNP 438
            |...||||.|||:|||:|.::.|...:..:|:.:.|||||..:||||.:||||::|:|.....|.
Zfish   325 LVSSENSASIFNTLSDLPSQLEDGAAVLGEAVRLAGSLSQENLDTHRHKHLAYILAEQAQLNSNN 389

  Fly   439 EAAPNLPKQQLARRQVRKSKSILEAFLFRGDGNEGDQLKNKNIRQTEILVDLREAILKVGRHFIT 503
            ..:.|....::.|||..:.||.|.:.|:..|  |.:.||.|||:|||::..|||||.:...||..
Zfish   390 SHSLNTNLNKVVRRQNMRRKSTLSSLLWGED--EVEALKAKNIKQTELVAALREAINRTAEHFHC 452

  Fly   504 IEPKLAGHIQLTANYSTESHAKDHENFINVARTRKRRAKALHDFERHDDDELGFRRNDIITIISQ 568
            ::|:... ..||.:||.|||.:|||||:.|:|.|:||||||.|||||||||||||:|||||||||
Zfish   453 LDPRNCS-TDLTPDYSMESHQRDHENFLVVSRNRRRRAKALLDFERHDDDELGFRKNDIITIISQ 516

  Fly   569 KDEHCWVGELNGLRGWFPAKFVELLDERSKLYTSAGDDAISETVTDLVRGTLAPAIKAFLEHGMK 633
            |||||||||||||||||||||||:||||||.|:.||||.::|.|.|||||:|.||:||..:||:|
Zfish   517 KDEHCWVGELNGLRGWFPAKFVEILDERSKEYSLAGDDTVTEAVNDLVRGSLCPALKAIFQHGLK 581

  Fly   634 RPTFLGGPIHPWLYIEEAATREVEKDFESVYSRLVLCKTYRLDEDGKVLTPEELLYRCVQAINQT 698
            :|:.||||.||||:|||||::|||:||.|||||||||||||||||||||||||||||.||::|.:
Zfish   582 KPSILGGPCHPWLFIEEAASKEVERDFNSVYSRLVLCKTYRLDEDGKVLTPEELLYRAVQSVNMS 646

  Fly   699 HDDAHAQMDVKLRSLICLGLNEQVLHLWLEVLCACQEVVQKWYHSWSFIDSPGWVQIKCELRILS 763
            ||.||.|||||.|||||:|||||||||||||||:....|:||||.|||:.||||||||||||:||
Zfish   647 HDTAHVQMDVKFRSLICVGLNEQVLHLWLEVLCSSMSAVEKWYHPWSFLRSPGWVQIKCELRVLS 711

  Fly   764 QFAFNLNPDWELPPKR-GKESQPLKDGVRDMLVKHHLFSWDL 804
            :|||:|:.|.|||.|: .||.:|||:||:||||||||||||:
Zfish   712 KFAFSLSQDCELPTKKEEKEQRPLKEGVQDMLVKHHLFSWDI 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	142/213 (67%)
		SH3_SGSM3	540..592	CDD:212747	49/51 (96%)
		RUN	619..773	CDD:280855	114/153 (75%)
sgsm3	NP_998495.1	TBC	112..326	CDD:214540	142/213 (67%)
		SH3_SGSM3	488..540	CDD:212747	49/51 (96%)
		RUN	567..720	CDD:280855	114/152 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575690
Domainoid	1	1.000	300	1.000	Domainoid score	I1403
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9249
Inparanoid	1	1.050	976	1.000	Inparanoid score	I297
OMA	1	1.010	-	-		QHG48054
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	1	1.000	-	-		FOG0007050
OrthoInspector	1	1.000	-	-		oto39564
orthoMCL	1	0.900	-	-		OOG6_107028
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	1	1.000	-	-		X5135
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800