DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and CG7324

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_649305.1	Gene:	CG7324 / 40361	FlyBaseID:	FBgn0037074	Length:	1291	Species:	Drosophila melanogaster

Alignment Length:	933	Identity:	191/933 - (20%)
Similarity:	334/933 - (35%)	Gaps:	316/933 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 EEEDGPEQSSNKLL-----SIPF--------------VEDAQQRLQWIAHLEFSHNKEAAELSWE 145
            :::||.::..|:::     ::||              :.|...|:    |:..|..:...::||.
  Fly   348 KKDDGQQRFENQIVIITSENVPFMFAHIVDRAVLISKITDLLARV----HVPLSRERAKYDISWS 408

  Fly   146 HVDVMLP-----------------------------------RTEKLRNMVRQGIPHTLRAQMWM 175
            ....::.                                   ||..:.|::.:|||..||.::|:
  Fly   409 KQTALMNTFKTQFSAEIIQKQEEKMVRWEAHFRDFGRGIGMFRTTDVINLIVEGIPDKLRQEIWL 473

  Fly   176 RLSGALAKKQKSETSYHDIV-KASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILR 239
            ..|||:..|:.:...|.|:| ||:.........:|::||.|.||.:..|.:.:|.|  .|||:|:
  Fly   474 IFSGAIHDKEMNPGLYEDLVEKAACIKNCFAHDEIDRDLPRSLPEHPAFQSTDGIG--ALRRVLQ 536

  Fly   240 GIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTL 304
            ..|...|.:||||...::.:..|||.:|||||||:|::.|:||| .||...::|.|.||.|::.|
  Fly   537 AYALRNPQVGYCQAMNIVSSVFLLFCDEENAFWMLASLCENLLP-DYYKDKVVGAQIDQGVLNEL 600

  Fly   305 IANYLSSVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKV 369
            :..:|..:...|.:..: :.:|::.||||:|.:|:..:..:.|.|.|||||:.::|.::|.:::.
  Fly   601 VETHLPDLHGHLEQLGV-IKMISISWFLTIFMSVISYESSLHILDCFFYEGAKIIFMISLQIIEW 664

  Fly   370 KEQDLKHLENSAQ-----------IFNSLSDIPGEVTD------------VEVLFRQA-LEVGGS 410
            ....|...::..:           ::|....:| ..||            |:.|..:| .:.|..
  Fly   665 NRDKLLICQDDGEAMLVLQNYLEGVYNPEYQVP-PTTDKRKMERKVQTQTVQTLIHEAYTKFGED 728

  Fly   411 LSQTVIDTHRRRH---------------------------------LAYLMADQGHQIGNPE--- 439
            ::|..|:..|.:|                                 |..::.::.|.:.:.:
  Fly   729 ITQQRIEELRNKHRRLTMRQFDIDNEKTIVKAYVQNPYFNRSELHMLLTIIREEKHALKSLQQQQ 793

  Fly   440 --------AAPNLPKQQLAR--RQVRKSKSILEAF----------------------------LF 466
                    ..|.|..|..:|  :....|....||:                            ||
  Fly   794 QKVQCPLSETPQLVPQSTSRPIQDAGASGGRYEAYSVSYEVFHTLFTELTPWRKCVSVDIGEKLF 858

  Fly   467 RGDGNEG------DQL--------KNKNIRQTEILVDLREAILKVGRHFITIEPKLAGHIQLTAN 517
            |....:|      .||        .|||:.:.::|             ::...|.|....::..:
  Fly   859 RLTDKKGTGVLDFGQLINALGLVCSNKNMEKLKLL-------------YVLHLPPLLSKAEIERS 910

  Fly   518 YSTESHAKDH-------ENFINVARTRKRRA---KALHDFERHDDDELGFRRNDIITIISQKDEH 572
            .......||.       |:|.:...:....|   .:.|:|:..|           ..:|| ..:|
  Fly   911 RRPRPRTKDDAEEAFEAEDFFDNDASESMEALPSPSDHNFDADD-----------FALIS-ATQH 963

  Fly   573 CWVGELNGLRGWFPAKFVEL--------------LDERSKLY-------------TSAGD----- 605
                 |:.|.|.....|::|              |..||..:             |.||.
  Fly   964 -----LHNLAGISGNTFMDLSRTPNLSVNSNTSSLAHRSSTFYVDLPGFQGTATSTDAGRDEDEL 1023

  Fly   606 -------------DAISETVTDLVRGTLAPAIKAFLEHGMKRPTFLGGPI-----HPWLYIEE-- 650
                         |..|: ::||....:.|.     |.|:......|...     |..|.:|.
  Fly  1024 QRQLRQQGRYESIDTFSD-ISDLGAARITPP-----EAGVGADVVAGAASSAAADHMLLNVETIS 1082

  Fly   651 ---------AATREVEKDFESVYSRLVLCKTYRLDEDGKVLTPEELLYRCVQAINQTHDDAHAQM 706
                     ||||....|..:...|.:....|.||:      |:|      .|.|..|...|.:.
  Fly  1083 NFSQISDLVAATRLERVDSNATDLRSLGSLGYLLDQ------PDE------GASNSQHSIPHMRK 1135

  Fly   707 DVKLRSLICLGLNEQVLHLW---LEVLCACQ-EVVQKWYHSWSFIDSPGWVQIKCELRILSQFAF 767
            :           |.|:  ||   :|::...| |.:|:.|.:   :...|...||.|..:.|....
  Fly  1136 E-----------NFQL--LWRSIIEIMGLVQDEEMQRAYEN---LLELGNSNIKKEPSLESFTQL 1184

  Fly   768 NLNPDWELPPKRGKESQPLKDGV 790
            |:..| |.|...|..:.|..:.:
  Fly  1185 NMGGD-EQPDSNGNPTTPAPEPI 1206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	75/214 (35%)
		SH3_SGSM3	540..592	CDD:212747	11/54 (20%)
		RUN	619..773	CDD:280855	37/173 (21%)
CG7324	NP_649305.1	PH-GRAM1_TCB1D8_TCB1D9_family	147..249	CDD:275404
		PH-GRAM2_TCB1D9_TCB1D9B	293..389	CDD:270161	6/40 (15%)
		TBC	462..670	CDD:214540	75/211 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456642
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.870