Protein Alignment CG12241 and GAPcenA

DIOPT Version :10

• Sequence 1: NP_650432.1
• Gene: CG12241 / 41834
• FlyBaseID: FBgn0038304
• Length: 804
• Species: Drosophila melanogaster
• Sequence 2: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Alignment Length: 622
• Identity: 130/622 - (20%)
• Similarity: 232/622 - (37%)
• Gaps: 160/622 - (25%)

  Fly    99 VEEEDGPEQSSNKL-------------LSIPFVED----------AQQRLQWIAHLEFSHNKEAA 140
            :.|:.|.:|||:.|             .||..:||          .:..|.....:    :|:.:
  Fly   563 ITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSSDGDEPLLSGTGEV----SKDCS 623

  Fly   141 ELSWEHVDVML------PRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASS 199
            :.:.:..|.:|      .|.:.|..:||.|:|..||.::|.:|:....:.:.:: .|..::...:
  Fly   624 QDTLDEWDPILREWDSEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMND-KYKILITKET 687

  Fly   200 NDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLF 264
            ..:.:    |::|:.|..|.:.||....|:|...|.::.:..|....::|||||...|.|.|||.
  Fly   688 KCETV----IQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLH 748

  Fly   265 MEEENAFWMMATI-----VEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELS 324
            |.||:||.::..:     :.||..|.:   .:|.::..|  :..||.:.|..:.|......||..
  Fly   749 MPEEDAFCVLVALMYDYGLRDLYKAGF---EVLYLRLYQ--LERLIKDQLPKLHEHFTACGIETH 808

  Fly   325 LITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLENSAQIFNSLSD 389
            :....|||||:.....:..:..:.|.|..:|..||||:.:.:|.:.|.||:.|:     |..:
  Fly   809 MYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLD-----FEGI-- 866

  Fly   390 IPGEVTDVEVLFRQALEVGGSLSQTVIDTHRRRHLAYLMADQGHQIGNPEAAPNLPKQQLARRQV 454
                                              |.|.......:..:...|..:.| |...|::
  Fly   867 ----------------------------------LKYFRVTLPKKCRSSSQARKVMK-QACERKI 896

  Fly   455 RKSKSILEAFLFRGDGNEGDQLKNKNIRQTEILVDLREAILKVGRHFITIEPKLAGHI-----QL 514
            :|.|...|.||          ||.::..:.|     :||.:...| |.....|:...|     ||
  Fly   897 KKLKQYEEEFL----------LKKQHKERLE-----KEAQIYENR-FGEERRKMQAEIDALNKQL 945

  Fly   515 T-ANYSTESHAKDHENFINVARTRKRRAKALHDFERHDDDELGFRRNDIITIISQKDEHCWVGEL 578
            | |........|.|...|       :..|.:...:..|.:.|......::.::|...: |
  Fly   946 TSAKERAVEKEKKHTGII-------QEYKQIIQRQEQDMNTLSETLGKVMHMVSNCQD-C----- 997

  Fly   579 NGLRGWFPAKFVELLDERSKLYTSAGDDAISETVTDLVRGTLAPAIKAFLEHGMKRPTFLGGPIH 643
                    .:.::..::.:|     .||..:...||.:|..        .||.:       ||:.
  Fly   998 --------QQQIDAGNDNAK-----SDDGKNRGQTDAMRNA--------NEHPL-------GPLD 1034

  Fly   644 PWLYIEEAATREVEKDFESVYSRLVL----CKTYRLD 676
            |   :..|:.|..|.:.|...::|..    ||...|:
  Fly  1035 P---LNAASQRIRELELELAQAKLAQVEAECKNQDLN 1068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	60/218 (28%)
		SH3_SGSM3	540..592	CDD:212747	5/51 (10%)
		RUN_SGSM3	570..783	CDD:439050	20/111 (18%)
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	377..523	CDD:463599
		TBC	650..858	CDD:214540	59/217 (27%)
		SMC_prok_B	<876..>1087	CDD:274008	49/254 (19%)
		TPH	<883..>977	CDD:464007	26/117 (22%)