DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG12241 and Tbc1d2

DIOPT Version :9

Sequence 1:NP_650432.1 Gene:CG12241 / 41834 FlyBaseID:FBgn0038304 Length:804 Species:Drosophila melanogaster
Sequence 2:XP_006538109.1 Gene:Tbc1d2 / 381605 MGIID:2652885 Length:923 Species:Mus musculus


Alignment Length:492 Identity:142/492 - (28%)
Similarity:228/492 - (46%) Gaps:111/492 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 RKLQN-LGSEDDLGELPPMMEELSVADGLRPNPGGPFSALTASMWPQEILAKLGGGAELASGPND 86
            |:||. .|:|  .|:.|.::::|.                      ||.|....|.|: :.|.:.
Mouse   512 RRLQEAAGAE--AGDFPELLQQLI----------------------QEALQWEAGEAD-SVGLSP 551

  Fly    87 QPEYRFDEFGFRVEEEDGPEQSSNKLLSIP--FVEDAQ-----QRLQWIAHLEFSHNKEAAEL-- 142
            ..||  |::||               |::|  .:||.:     |.|:..:|...:|  ||.|.  
Mouse   552 VSEY--DDYGF---------------LTVPDYEMEDLKLLAKIQALEVRSHHLLAH--EAVERPL 597

  Fly   143 --SWEHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMT 205
              .|..:..:.|..| |:.::|.|:|...|.::|..|.....:..::...|.:::......:...
Mouse   598 RDRWATLTELTPSAE-LKQLLRAGVPREHRPRVWRWLVHRRVRHLQAPGCYQELLARGRACEHPA 661

  Fly   206 SKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFME-EEN 269
            ::|||.||.|..|||..|:.|..:...:|||:|...:|..|.||||||...:.|..||.:| ||:
Mouse   662 ARQIELDLNRTFPTNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEDEES 726

  Fly   270 AFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLITLHWFLTL 334
            |||.:..|||.:|||.|||.||...|.||||:..|::..|..:...|.:|.::|||||.:|||.:
Mouse   727 AFWCLVAIVETILPAEYYSKTLTASQVDQRVLQDLLSEKLPRLTAHLGQHRVDLSLITFNWFLVV 791

  Fly   335 FANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLENSAQIFNSLSDIPGEVTDVEV 399
            ||:.:...||:|:||.|.|||:.|:|:..|.:.|..|:.:..|::|.:|:..|.           
Mouse   792 FADSLISDILLRVWDAFLYEGTKVVFRYALAIFKYNEEAILQLQDSLEIYQYLR----------- 845

  Fly   400 LFRQALEVGGSLSQTVIDTHRRRHLAYLMADQGHQIGNPEAAPNLPKQQLARRQVRKS-KSILEA 463
                      ..::|:.|:.:...:|:  .|.     ||     .|.:||  ||:|.: :..|||
Mouse   846 ----------FFTKTICDSRKLMSIAF--NDM-----NP-----FPMKQL--RQLRAAHRERLEA 886

  Fly   464 FLFRGDGNEGDQLKNKNIRQTEIL-VDLREAILKVGR 499
                            .:|:.|:| |:..:....:||
Mouse   887 ----------------ELRELELLKVEYLQRRASLGR 907

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12241NP_650432.1 TBC 161..375 CDD:214540 83/214 (39%)
SH3_SGSM3 540..592 CDD:212747
RUN 619..773 CDD:280855
Tbc1d2XP_006538109.1 PH_TBC1D2A 45..146 CDD:269966
PRK14951 <192..404 CDD:237865
COG4913 <300..>565 CDD:227250 20/94 (21%)
TBC 620..832 CDD:214540 82/211 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5210
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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