DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and Tbc1d10b

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_001102391.1	Gene:	Tbc1d10b / 365372	RGDID:	1309191	Length:	795	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	127/489 - (25%)
Similarity:	205/489 - (41%)	Gaps:	101/489 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EHTRKLQNLGSEDDL--------GELPPMMEELSVADGLRPNPGGPFSALTASMWPQEILAKLGG 76
            |.|...|:|||...|        |:.|   :.||..|.: ....|...:||      :.::.:|.
  Rat   221 ETTENFQDLGSTSSLGPGISGPRGQAP---DTLSYLDSV-SLMSGTLESLT------DDVSSVGS 275

  Fly    77 GAELASGPNDQPEYRFDEFGFRVEEEDGPEQSSNKLLSIPFVEDAQQR-LQWIAHLEFSHNKEAA 140
            .:|:    |.....:.|::||.    .|.:.|.:...||| |:.|:|| |:|   ||...|.:
  Rat   276 DSEI----NGLALRKTDKYGFL----GGSQYSGSLESSIP-VDVARQRELKW---LEMFSNWD-- 326

  Fly   141 ELSWEHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMT 205
              .|     :..|.:|::...|:|||.:|||:.|..||.:....:::...:.::.:|..:.:.:
  Rat   327 --KW-----LSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWL- 383

  Fly   206 SKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEENA 270
             ..|||||.|..|.:..|:...|.|...|.|||:......||.||||....:.|.||:.|..|.|
  Rat   384 -DVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQA 447

  Fly   271 FWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLITLHWFLTLF 335
            ||.:..|.:..|| .|||:.|..||.|..:...|:..........||:..|:..|....||:.:|
  Rat   448 FWCLVQICDKYLP-GYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIF 511

  Fly   336 ANVVHMKILVRIWDWFFYEGSIVLFQLTL-----------------GMLKVKEQDLKHLENSAQ- 382
            |..:....::|:||.||.||..::|::.|                 ||.:..|| |::|.....
  Rat   512 ARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQ-LRNLPQQCMQ 575

  Fly   383 ---IFNSLSDIPGEVTDV------------------EVLFRQALEVGGSLSQTVIDTHRRRHLAY 426
               :.:.::.:|  ||:.                  |:.:|.:..:.||   ..|...|||.
  Rat   576 EDFLVHEVTTLP--VTEALIERENAAQLKKWRETRGELQYRPSRRLHGS---RAIHEERRRQ--- 632

  Fly   427 LMADQGHQIGNPEAAPNLPKQQLARRQVRKSKSI 460
                      .|...|:.....|...:.|.|:::
  Rat   633 ----------QPPLGPSSSLLSLPSLKSRGSRAV 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	71/230 (31%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
Tbc1d10b	NP_001102391.1	TBC	340..545	CDD:214540	67/207 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810