DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and Sgsm3

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_942082.2	Gene:	Sgsm3 / 362963	RGDID:	735113	Length:	763	Species:	Rattus norvegicus

Alignment Length:	755	Identity:	489/755 - (64%)
Similarity:	607/755 - (80%)	Gaps:	16/755 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PNPGGPFSALTASMWPQEILAKLGGGAELASGPND--QPEYRFDEFGFRVEEEDGPEQSSNKLLS 114
            |:..|||||||.|:||||||||       :|...|  :||..:|||||||::| |.|...:::..
  Rat    21 PSASGPFSALTPSIWPQEILAK-------SSQKEDSSEPEICYDEFGFRVDKE-GSEPGCSQMAG 77

  Fly   115 IPFVEDAQQRLQWIAHLEFSHNKEAAELSWEHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSG 179
            .|.|||..|||:|.|||||:||.:..:|:|:.:.|.|||:||||::|..||||.:|.|:||||||
  Rat    78 TPLVEDPPQRLRWQAHLEFTHNHDVGDLTWDKIAVSLPRSEKLRSLVLAGIPHGMRPQLWMRLSG 142

  Fly   180 ALAKKQKSETSYHDIVKASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWL 244
            ||.||:.||.||.:|||.||||:.:.:|||||||||.:|:||||:|.|..|:|||||:||.:|||
  Rat   143 ALQKKKNSELSYREIVKNSSNDETIAAKQIEKDLLRTMPSNACFANVNSIGVPRLRRVLRALAWL 207

  Fly   245 FPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYL 309
            :|:||||||||::.||||||:|||:|||||..|:||||||||:|:||||:|.||||:..||..||
  Rat   208 YPEIGYCQGTGMVAACLLLFLEEEDAFWMMCAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYL 272

  Fly   310 SSVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDL 374
            ..:|:.|::|||||||||||||||.||:|||:::|:||||.||||||:||||.|||||::||::|
  Rat   273 PRLDKLLQEHDIELSLITLHWFLTAFASVVHIRLLLRIWDLFFYEGSLVLFQTTLGMLRLKEEEL 337

  Fly   375 KHLENSAQIFNSLSDIPGEVTDVEVLFRQALEVGGSLSQTVIDTHRRRHLAYLMADQGHQIGNPE 439
            ...||||.|||:|||||.::.|.|:|..:|:::.|||:...::|.||:|||||:||||..:|
  Rat   338 IQSENSASIFNTLSDIPAQMDDAELLLGEAMQLAGSLTDVAVETQRRKHLAYLIADQGQTLG--- 399

  Fly   440 AAPNLPKQQLARRQVRKSKSILEAFLFRGDGNEGDQLKNKNIRQTEILVDLREAILKVGRHFITI 504
            .:......|:.||:.::.||.:.:.||..|..|.  ||.|||:|||::.|||||||:|.|||...
  Rat   400 TSTTTSLSQVVRRRTQRRKSGITSLLFGEDDLEA--LKAKNIKQTELVADLREAILRVARHFQCT 462

  Fly   505 EPKLAGHIQLTANYSTESHAKDHENFINVARTRKRRAKALHDFERHDDDELGFRRNDIITIISQK 569
            :||... ::||.:||.|||.:||||::...|:.:||||||.|||||||||||||:||||||||||
  Rat   463 DPKNCS-VELTPDYSMESHQRDHENYVACLRSHRRRAKALLDFERHDDDELGFRKNDIITIISQK 526

  Fly   570 DEHCWVGELNGLRGWFPAKFVELLDERSKLYTSAGDDAISETVTDLVRGTLAPAIKAFLEHGMKR 634
            ||||||||||||||||||||||:||||||.|:.||||:::|.|||||||||.||:||..|||:|:
  Rat   527 DEHCWVGELNGLRGWFPAKFVEVLDERSKEYSIAGDDSVTEGVTDLVRGTLCPALKALFEHGLKK 591

  Fly   635 PTFLGGPIHPWLYIEEAATREVEKDFESVYSRLVLCKTYRLDEDGKVLTPEELLYRCVQAINQTH 699
            |:.|||..||||:|||||.||||:||:|||||||||||||||||||||||||||||.||::|.||
  Rat   592 PSLLGGACHPWLFIEEAAGREVERDFDSVYSRLVLCKTYRLDEDGKVLTPEELLYRAVQSVNVTH 656

  Fly   700 DDAHAQMDVKLRSLICLGLNEQVLHLWLEVLCACQEVVQKWYHSWSFIDSPGWVQIKCELRILSQ 764
            |.||||||||||||||:|||||||||||||||:....|:|||..|||:.||||||||||||:|..
  Rat   657 DAAHAQMDVKLRSLICVGLNEQVLHLWLEVLCSSLPTVEKWYQPWSFLRSPGWVQIKCELRVLCC 721

  Fly   765 FAFNLNPDWELPPKRGKESQPLKDGVRDMLVKHHLFSWDL 804
            |||:|:.|||||.||.:|.||||:||:||||||||||||:
  Rat   722 FAFSLSQDWELPAKREEEKQPLKEGVQDMLVKHHLFSWDI 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	145/213 (68%)
		SH3_SGSM3	540..592	CDD:212747	49/51 (96%)
		RUN	619..773	CDD:280855	117/153 (76%)
Sgsm3	NP_942082.2	TBC	127..338	CDD:214540	144/210 (69%)
		SH3_SGSM3	497..549	CDD:212747	49/51 (96%)
		RUN	576..727	CDD:397055	116/150 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336545
Domainoid	1	1.000	310	1.000	Domainoid score	I1283
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9249
Inparanoid	1	1.050	1015	1.000	Inparanoid score	I268
OMA	1	1.010	-	-		QHG48054
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	1	1.000	-	-		FOG0007050
OrthoInspector	1	1.000	-	-		oto96509
orthoMCL	1	0.900	-	-		OOG6_107028
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5135
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770