DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and Tbc1d10a

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_001015022.1	Gene:	Tbc1d10a / 360968	RGDID:	1311641	Length:	505	Species:	Rattus norvegicus

Alignment Length:	397	Identity:	107/397 - (26%)
Similarity:	179/397 - (45%)	Gaps:	38/397 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 MEELSVADGLR-PNPGGPFSALTASM--WPQ----EILAKLGGGAELASGPNDQPEYRFDEFGFR 98
            |.:.|..:|.| |..||..|....|:  .|.    :.|:.||..:|    .|...|.|.|:|||.
  Rat     1 MAKSSRENGPRAPASGGSLSGTRESLAQGPDAATADELSSLGSDSE----ANGFAERRIDKFGFI 61

  Fly    99 VEEEDGPEQSSNKLLSIPFVEDAQQRLQWIAHLEFSHNKEAAELSWEHVDVMLPRTEKLRNMVRQ 163
            |    |.:.:...|..:|.....|:..:|:..|.          :|:  ..|..:.:|:|...::
  Rat    62 V----GSQGAEGALEEVPLEVLRQRESKWLDMLN----------NWD--KWMAKKHKKIRLRCQK 110

  Fly   164 GIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMTSKQIEKDLLRILPTNACFSNPNG 228
            |||.:||.:.|..|||...|.|::...:.::..:..:.:.:  ..||:||.|..|.:..|.:..|
  Rat   111 GIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWL--DVIERDLHRQFPFHEMFVSRGG 173

  Fly   229 TGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYYSSTLLG 293
            .|...|.|:|:......|:.||||....|.|.||:.|..|.|||.:..:.|..|| .|||..|..
  Rat   174 HGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQVCEKYLP-GYYSEKLEA 237

  Fly   294 IQADQRVMHTLIANYLSSVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIV 358
            ||.|..::.:|:........:.|.:..|:..|....||:..||..:....::|:||.||.||..:
  Rat   238 IQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFARTLPWSSVLRVWDMFFCEGVKI 302

  Fly   359 LFQLTLGMLK---VKEQDLKHLENSAQIFNSLSDIPGEVTDVEVLFRQALEVGGSLSQTVIDTHR 420
            :|::.|.:||   ...:.|:..:...:....|..:..::.....|.::.:|:  .:::..|:
  Rat   303 IFRVGLVLLKHALGSPEKLRACQGQYETIEQLRSLSPKIMQEAFLVQEVIEL--PVTERQIE--- 362

  Fly   421 RRHLAYL 427
            |.||..|
  Rat   363 REHLIQL 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	66/216 (31%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
Tbc1d10a	NP_001015022.1	TBC	110..313	CDD:214540	65/205 (32%)
Tbc1d10a	NP_001015022.1	VCX_VCY	404..>501	CDD:291884
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810