DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and Tbc1d14

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_001106836.1	Gene:	Tbc1d14 / 360956	RGDID:	1309993	Length:	714	Species:	Rattus norvegicus

Alignment Length:	441	Identity:	101/441 - (22%)
Similarity:	174/441 - (39%)	Gaps:	112/441 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 QPEYRFDEFGFRVEEEDGPEQSSNKLL-----------------SIPF--VEDAQQRLQ----WI 128
            |.||. |:.| |......|:|:..|.|                 ::|.  .|:||:..|    .:
  Rat   301 QKEYE-DKAG-RPSRPPSPKQNVRKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMV 363

  Fly   129 AHLEFSHNKEA-------------------AELSWEHVDVMLPRTE------KLRNMVRQGIPHT 168
            ...:....|||                   |.|:|.  :.:||..|      |:|::..||||.:
  Rat   364 VQAKKRELKEAQRRKKQLEERCKVEESIGNAVLTWN--NEILPNWETMWCSKKVRDLWWQGIPPS 426

  Fly   169 LRAQMWMRLSG--------------ALAKKQ-------KSETSYHDIVKASSNDQLMTSKQIEKD 212
            :|.::|....|              |.||::       .||....| ...|:.|:..:.:.|:.|
  Rat   427 VRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENED-AGFSAADREASLELIKLD 490

  Fly   213 LLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATI 277
            :.|..| |.|.....|.....|..||.......||:||.||...|.|.|:|.::..:||...:.:
  Rat   491 ISRTFP-NLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNL 554

  Fly   278 VEDLLPASYYSSTLLGIQADQRVMHTLIANYLSS----VDESL-------RKHDIELSLITLHWF 331
            :......:::           ||.|.|:..|.::    .:|:|       :|:::...:..:.|.
  Rat   555 LNKPCQMAFF-----------RVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTADIYLIDWI 608

  Fly   332 LTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLE--NSAQIFNSL-SDIPGE 393
            .||::..:.:.:..||||.|..:|...||:..||:||:.|..|..::  :|||....| .|:|.:
  Rat   609 FTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDILTRMDFIHSAQFLTRLPEDLPAD 673

  Fly   394 VTDVEVLFRQALEVGGSLSQTVIDTHRRRHLAYLMADQGHQIGNPEAAPNL 444
                        :|..::|...:.:..::....|.|.|.......:.:|:|
  Rat   674 ------------DVFAAISTVQMQSRNKKWAQVLSALQKDSREMEKGSPSL 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	61/245 (25%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
Tbc1d14	NP_001106836.1	DUF4207	147..384	CDD:290615	18/84 (21%)
Tbc1d14	NP_001106836.1	TBC	419..651	CDD:214540	61/244 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810