Protein Alignment CG12241 and Evi5

DIOPT Version :10

• Sequence 1: NP_650432.1
• Gene: CG12241 / 41834
• FlyBaseID: FBgn0038304
• Length: 804
• Species: Drosophila melanogaster
• Sequence 2: NP_727526.2
• Gene: Evi5 / 32088
• FlyBaseID: FBgn0262740
• Length: 807
• Species: Drosophila melanogaster
• Alignment Length: 721
• Identity: 164/721 - (22%)
• Similarity: 293/721 - (40%)
• Gaps: 137/721 - (19%)

  Fly    62 TASMWPQEILAKLGGGAELASGPNDQPEYRFD-----EFGFRVEEEDGPEQSSNKLLSIPFVE-- 119
            |||....:....:.|||  ..|..:.|....|     |...::.|.|.  :|.|.|.|....:
  Fly     8 TASSAESQAKMDVKGGA--LPGEENLPTSEMDLLAKLEAANKLIESDA--KSLNSLHSTHSRKNS 68

  Fly   120 DAQQRLQWIAHLEFSHNKEAAELSWEHVDVMLPRTE---KLRN-----MVRQGIPHTLRAQMWMR 176
            |..|     ..|..|.|..|.|..|.....:|...|   |.:|     :||:||||..||.:|.:
  Fly    69 DTSQ-----ISLTSSGNSVAEEDIWTTWATILNDWEGALKRKNPCVSELVRRGIPHHFRAIVWQQ 128

  Fly   177 LSGAL--AKKQKSETSYHDIVKASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILR 239
            ||||.  .|||     |.:.:||:|    ...|.|.:|:.|..|....|...:|.|...|..:::
  Fly   129 LSGASDGDKKQ-----YAEYIKATS----ACEKVIRRDIARTYPEVEFFKEKDGPGQEALFNVIK 184

  Fly   240 GIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYYSSTL--LGIQADQRVMH 302
            ..:....::|||||:|.||..||:.|.||.||.::..|::.......:..::  ||:...|  :.
  Fly   185 AYSLHDREVGYCQGSGFIVGLLLMQMPEEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQ--LE 247

  Fly   303 TLIANYLSSVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGML 367
            .|:...:..:....::...:.::....|||||:...:::.:..||.|.|..||...:|::.|.:|
  Fly   248 NLVQEQIPDMHIHFQQQGFQTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALL 312

  Fly   368 KVKEQDLKHLENSAQIFNSLSDIPGEV-TDVEVLFRQALEVGGSLSQTVIDTHRRRHLAYLMADQ 431
            ...:..|..|:..|.:.....::||.| .|||..|..|..:       .::|.|.:.:     ::
  Fly   313 LTGKDTLLCLDMEAMLKFFQKELPGRVEADVEGFFNLAYSI-------KLNTKRMKKM-----EK 365

  Fly   432 GHQIGNPEAAPNLPKQQLARRQ---VRKSKSILEA-------FLFRGDGNEGDQLKNKNIRQTEI 486
            .:|....:....:.:.:..||:   :::...:|||       .|.||..:..::.:.....|||
  Fly   366 EYQDLKKKEQEEMAELRRLRRENCLLKQRNELLEAESAELADRLVRGQVSRAEEEETSYAIQTE- 429

  Fly   487 LVDLREAILKVGRHFITIEPKLAG-HIQLTANYSTESHAKDHENFINVARTRKRRAKALHDFERH 550
            |:.||.:.|:|.........::.| .::|            .||.:::.....|::..
  Fly   430 LMQLRRSYLEVSHQLENANEEVRGLSLRL------------QENNVSIDSNNSRQSSI------- 475

  Fly   551 DDDELGFRRNDIITIISQKDE--HCWVGELNGLRGW----------FPAKFVELLDERSKLYTSA 603
              |||..:..    .:.|:||  .|.:.||..:|..          ..||..||.:::..|..:.
  Fly   476 --DELCMKEE----ALKQRDEMVSCLLEELVKVRQGLAESEDQIRNLKAKVEELEEDKKTLRETT 534

  Fly   604 GDDAISETVTDLVRGTLAPAIKAFLEHGMKRPTFLGGPIHPWLYIEEAAT---REVEKDFESVYS 665
            .|::::....:|:...|..|..:.....:|:            .::|.::   |::.::..|...
  Fly   535 PDNSVAHLQDELIASKLREAEASLSLKDLKQ------------RVQELSSQWQRQLAENQRSESE 587

  Fly   666 RLVLCKTYRLDEDGKVLTPEELLYRCVQAINQTHDDAHAQ------MDVKLRSLICLGLNEQVLH 724
            |    .|..:|.     ||::||   ....:.:....|.|      |..::|.:..|   .::..
  Fly   588 R----TTNAVDS-----TPKKLL---TNFFDSSKSSEHTQKLEEELMTTRIREMETL---TELKE 637

  Fly   725 LWLEVL 730
            |.|:|:
  Fly   638 LRLKVM 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	63/217 (29%)
		SH3_SGSM3	540..592	CDD:212747	12/63 (19%)
		RUN_SGSM3	570..783	CDD:439050	34/182 (19%)
Evi5	NP_727526.2	TBC	113..320	CDD:214540	63/217 (29%)
		Smc	<358..>761	CDD:440809	61/344 (18%)