DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and Tbc1d2b

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	XP_006243590.1	Gene:	Tbc1d2b / 315880	RGDID:	1307436	Length:	963	Species:	Rattus norvegicus

Alignment Length:	445	Identity:	141/445 - (31%)
Similarity:	220/445 - (49%)	Gaps:	65/445 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 QEILAKLGGGAELASGPNDQPEY---------RFDEFGFRVEEEDGPEQSSNKLLSIPFVEDAQQ 123
            ::::|:|...| |.....:|||.         .||.:|||...:|..|:   ||:       |:.
  Rat   562 RDVIAQLLEDA-LQVESQEQPEQAFVKPHLVSEFDIYGFRTVPDDDEEE---KLV-------AKV 615

  Fly   124 RLQWIAHLEFSHNKEAAE-LSWEHVDVMLPRTE-----KLRNMVRQGIPHTLRAQMWMRLSGALA 182
            |...:..|..:.|:|.:. :.||:........|     :|:|::|.||||..|:::|........
  Rat   616 RALDLKTLYLTENQEVSTGVKWENYFASTMNREMVCSPELKNLIRAGIPHEHRSKVWKWCVDRHT 680

  Fly   183 KKQKS--ETSYHD-IVKASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWL 244
            :|.|.  |..|.. :::.:...|...|||||.||||.||.|..:|:|...||.:||.:|...:|.
  Rat   681 RKFKDSMEPGYFQALLQKALEKQNPASKQIELDLLRTLPNNKHYSSPTSEGIQKLRNVLLAFSWR 745

  Fly   245 FPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYL 309
            .||||||||...:||..||::|:|:|||.:.||||..:|..||:.||||.|.||||...|::..|
  Rat   746 NPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLLSEKL 810

  Fly   310 SSVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDL 374
            ..:.....::.::.:|||.:|||.:|.:.|...||.:|||.|.|||..|:|:..|.:.|.||:::
  Rat   811 PRLHTHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEI 875

  Fly   375 KHLENSAQIFNSLSDIPGEVTDVEVLFRQALEVGGSLSQTVIDTHRRRHLAY--LMADQGHQIGN 437
            ..|::|..||..|.                     ..::|::|..:...:::  |......||.|
  Rat   876 LKLQDSMSIFKYLR---------------------YFTRTILDARKLTSISFGDLNPFPLRQIRN 919

  Fly   438 PEAAPNLPKQQLARRQVRKSKSILEAFLFRGDGNEGDQLKNKNIRQTEILVDLRE 492
             ..|.:|.|   .|.::.:.::|.|.||     .|.|...:|.    |::.|..|
  Rat   920 -RRAYHLEK---VRLELTELEAIREDFL-----RERDTSPDKG----ELVSDEEE 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	90/216 (42%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
Tbc1d2b	XP_006243590.1	PH_TBC1D2A	36..144	CDD:269966
		PH	38..136	CDD:278594
		HIP1_clath_bdg	<339..>376	CDD:293123
		DUF1664	<346..436	CDD:285172
		RabGAP-TBC	708..876	CDD:278964	77/167 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820