DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and Rabgap1l

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	XP_006496938.1	Gene:	Rabgap1l / 29809	MGIID:	1352507	Length:	1051	Species:	Mus musculus

Alignment Length:	741	Identity:	153/741 - (20%)
Similarity:	266/741 - (35%)	Gaps:	199/741 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DDLGELPPMMEELSVADGLRP-NPGGPFSALTASMWPQEILAKLGGGAELASGPNDQPEYRFDEF 95
            |.:.|:..:..|....:.:.| :.|||.|       |||..|:.....||:||..|
Mouse   452 DAIYEVVSLQRESDKEEPITPTSAGGPMS-------PQEDEAEEESDNELSSGTGD--------- 500

  Fly    96 GFRVEEEDGPEQ---SSNKLLSIPFVEDAQQRLQWIAHLEFSHNKEAAELSWEHVDVMLPRTEKL 157
                ..:|.||:   |..:||.           :|       ||....            |.:.|
Mouse   501 ----VSKDCPEKILYSWGELLG-----------RW-------HNNLGG------------RPKGL 531

  Fly   158 RNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMTSKQIEKDLLRILPTNAC 222
            ..:|:.|:|..|||::|..|:|....::..:.....|.|.|:.:.::|     :|:.|..|.:..
Mouse   532 FTLVKSGVPEALRAEVWQLLAGCHDNQEMLDKYRILITKDSAQESVIT-----RDIHRTFPAHDY 591

  Fly   223 FSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYY 287
            |.:..|.|...|.:|.:..:....|||||||...:.|.|||.|.||.||.::.||:........|
Mouse   592 FKDTGGDGQESLYKICKAYSVFDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVTIMYGYKLRDLY 656

  Fly   288 SSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWDWFF 352
            .:....:......:..|:...|..:.......::|..:....||||||.....:.::..|.|...
Mouse   657 RNNFEDLHCKFYQLEKLMQEQLPDLYSHFCDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLL 721

  Fly   353 YEGSIVLFQLTLGMLKVKEQDLKHLENSAQIFNSLSDIPGEVTDVEVLFRQALEVGGSLSQTVID 417
            .||..::|.:.|.:||..::||..           :|..|.:.    .||..|.          .
Mouse   722 CEGLNIIFHVALALLKTSKEDLLQ-----------ADFEGALK----FFRVQLP----------K 761

  Fly   418 THRRRHLAYLMADQGHQIGNPEAAPNLPKQQLARRQVRKSKSILEAFLFRGDGNEGDQLKNKNIR 482
            .:|....|..:.:|...|..|  ...|.|.:...:.:|:::...|        :..|:.|.:|.|
Mouse   762 RYRAEENARRLMEQACNIKVP--TKKLKKYEKEYQAMRENQLQQE--------DPMDRYKRENRR 816

  Fly   483 QTEILVDLREAILKVGRHFITIEPKLAGHIQLTANYSTESHAKDHENFINVARTRKRRAKALHDF 547
            ..|..:.|.:....:....:|.:..|...:         ..|:|..:.:|
Mouse   817 LQEASMRLEQENDDLAHELVTSKIALRNDL---------DQAEDKADVLN--------------- 857

  Fly   548 ERHDDDELGFRRNDIITIISQKDEHCWVGELNGLRGWFPAKFVELLDERSKLYTSAGDDAISETV 612
                 .||.|.:.                           :.||..:|:.|      .:..:..:
Mouse   858 -----KELLFTKQ---------------------------RLVETEEEKRK------QEEETAQL 884

  Fly   613 TDLVRGTLAPAIKAFLEHGMKRPTF-------LGGPIHPWLYIEEAATREVEKDFESVYSRLVLC 670
            .::.|..|..|     |:.:|:.|.       :...:...|..::||::|   :.|:|..:::.|
Mouse   885 KEVFRKQLEKA-----EYEIKKTTAIIAEYKQICSQLSTRLEKQQAASKE---ELEAVKGKMMAC 941

  Fly   671 K--TYRLDEDGKVLTPEELLYRCVQAINQTH-----DDAHAQMDVKLRSLICLGLNEQVLHLWLE 728
            |  :....::| .|.|        .|:|:..     ||....:..:||.:. |.|.:..|.| :|
Mouse   942 KHCSDIFSKEG-ALKP--------VAVNREDQGLEADDEKDSLKKQLREME-LELAQTKLQL-VE 995

  Fly   729 VLCACQEV----------VQKWYHSW 744
            ..|..||:          :|...:||
Mouse   996 AKCKIQELEHQRGALMNEIQAAKNSW 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	58/213 (27%)
		SH3_SGSM3	540..592	CDD:212747	4/51 (8%)
		RUN	619..773	CDD:280855	33/150 (22%)
Rabgap1l	XP_006496938.1	PTB_Rab6GAP	129..257	CDD:269922
		DUF3694	290..421	CDD:372133
		RabGAP-TBC	541..744	CDD:366170	55/207 (27%)
		Smc	<814..>1019	CDD:224117	48/285 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810