Protein Alignment CG12241 and SGSM3

DIOPT Version :10

• Sequence 1: NP_650432.1
• Gene: CG12241 / 41834
• FlyBaseID: FBgn0038304
• Length: 804
• Species: Drosophila melanogaster
• Sequence 2: NP_001336968.1
• Gene: SGSM3 / 27352
• HGNCID: 25228
• Length: 766
• Species: Homo sapiens
• Alignment Length: 766
• Identity: 490/766 - (63%)
• Similarity: 603/766 - (78%)
• Gaps: 28/766 - (3%)

  Fly    56 GPFSALTASMWPQEILAKLGGGAELASGPNDQPEYRFDEFGFRVEEEDGPEQSSNKLLSIPFVED 120
            |||||||.|:||||||||.....|.|    :|||:.:|||||||.:|:|.|..|:.|.:.|.:||
Human    10 GPFSALTPSIWPQEILAKYTQKEESA----EQPEFYYDEFGFRVYKEEGDEPGSSLLANSPLMED 70

  Fly   121 AQQRLQWIAHLEFSHNKEAAELSWEHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQ 185
            |.|||:|.|||||:||.:..:|:|:.:.|.|||:||||::|..||||.:|.|:||||||||.||:
Human    71 APQRLRWQAHLEFTHNHDVGDLTWDKIAVSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKR 135

  Fly   186 KSETSYHDIVKASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGY 250
            .||.||.:|||.||||:.:.:|||||||||.:|:||||::....|:|||||:||.:|||:|:|||
Human   136 NSELSYREIVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGY 200

  Fly   251 CQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDES 315
            |||||::.||||||:|||:|||||:.|:||||||||:|:||||:|.||||:..||..||..:|:.
Human   201 CQGTGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKL 265

  Fly   316 LRKHDIELSLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLENS 380
            |::|||||||||||||||.||:||.:|:|:||||.||||||.||||||||||.:||::|...|||
Human   266 LQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENS 330

  Fly   381 AQIFNSLSDIPGEVTDVEVLFRQALEVGGSLSQTVIDTHRRRHLAYLMADQGHQIGNPEAAPNLP 445
            |.|||:|||||.::.|.|:|...|:.:.|||:...::|.||:|||||:||||..:| .....||
Human   331 ASIFNTLSDIPSQMEDAELLLGVAMRLAGSLTDVAVETQRRKHLAYLIADQGQLLG-AGTLTNL- 393

  Fly   446 KQQLARRQVRKSKSILEAFLFRGDGNEGDQLKNKNIRQTEILVDLREAILKVGRHFITIEPKLAG 510
             .|:.||:.::.||.:.|.||..|..|.  ||.|||:|||::.|||||||:|.|||...:||...
Human   394 -SQVVRRRTQRRKSTITALLFGEDDLEA--LKAKNIKQTELVADLREAILRVARHFQCTDPKNCS 455

  Fly   511 HIQLTANYSTESHAKDHENFINVARTRKRRAKALHDFERHDDDELGFRRNDIITIISQKDEHCWV 575
             ::||.:||.|||.:||||::..:|:.:||||||.|||||||||||||:||||||:|||||||||
Human   456 -VELTPDYSMESHQRDHENYVACSRSHRRRAKALLDFERHDDDELGFRKNDIITIVSQKDEHCWV 519

  Fly   576 GELNGLRGWFPAKFVELLDERSKLYTSAGDDAISETVTDLVRGTLAPAIKAFLEHGMKRPTFLGG 640
            ||||||||||||||||:||||||.|:.||||:::|.|||||||||.||:||..|||:|:|:.|||
Human   520 GELNGLRGWFPAKFVEVLDERSKEYSIAGDDSVTEGVTDLVRGTLCPALKALFEHGLKKPSLLGG 584

  Fly   641 PIHPWLYIEEAATREVEKDFESVYSRLVLCKTYRLDEDGKVLTPEELLYRCVQAINQTHDDAHAQ 705
            ..||||:|||||.||||:||.|||||||||||:|||||||||||||||||.||::|.|||..|||
Human   585 ACHPWLFIEEAAGREVERDFASVYSRLVLCKTFRLDEDGKVLTPEELLYRAVQSVNVTHDAVHAQ 649

  Fly   706 MDVKLRSLICLGLN-----------------EQVLHLWLEVLCACQEVVQKWYHSWSFIDSPGWV 753
            ||||||||||:|||                 ||||||||||||:....|:|||..|||:.|||||
Human   650 MDVKLRSLICVGLNQKGLELPLLPTPGHVPSEQVLHLWLEVLCSSLPTVEKWYQPWSFLRSPGWV 714

  Fly   754 QIKCELRILSQFAFNLNPDWELPPKRGKESQPLKDGVRDMLVKHHLFSWDL 804
            |||||||:|..|||:|:.|||||.|| :..||||:|||||||||||||||:
Human   715 QIKCELRVLCCFAFSLSQDWELPAKR-EAQQPLKEGVRDMLVKHHLFSWDV 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	144/213 (68%)
		SH3_SGSM3	540..592	CDD:212747	48/51 (94%)
		RUN_SGSM3	570..783	CDD:439050	163/229 (71%)
SGSM3	NP_001336968.1	TBC	114..325	CDD:214540	143/210 (68%)
		SH3_SGSM3	484..536	CDD:212747	48/51 (94%)
		RUN_SGSM3	514..744	CDD:439050	163/230 (71%)