DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and SPBC215.01

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_596678.2	Gene:	SPBC215.01 / 2540535	PomBaseID:	SPBC215.01	Length:	834	Species:	Schizosaccharomyces pombe

Alignment Length:	813	Identity:	183/813 - (22%)
Similarity:	309/813 - (38%)	Gaps:	226/813 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DHEGYVGREEHT---------RKLQNLGSEDDLGELPPMMEEL---SVADGLRPNPGGPFSALTA 63
            |:..:.|.:|..         ||:..:.|.|        :|:|   |.::|.........|..||
pombe    67 DYIAFQGDDESNQFCMPYTIIRKVSRVKSND--------LEQLLSVSTSNGYEYRISLQVSETTA 123

  Fly    64 SMWPQEILAKLGGGAELASGPNDQPEYRFDEFGFRVEEEDGPEQSSNKLLSIPFVEDAQQRLQWI 128
            :.:.| :|.:     ||.|...|.  .|..||.         :|..::.|..|.|.:.:.:..:.
pombe   124 AHFCQ-LLRE-----ELVSHKADM--QRSSEFS---------KQFFSERLCKPNVPEPETKDSYG 171

  Fly   129 AHLEFSH------NKEAAEL-SWEH------VDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGA 180
            ....:.:      ::|.|:| .|:.      .::.|.|......:||..:|:.||.::|...||:
pombe   172 FGARYGYPTDPRISRERAKLRMWKEYFLLYGANLSLIRVSLFSKLVRIELPNKLRGEIWELTSGS 236

  Fly   181 LAKKQKSETSYHDIVKASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLF 245
            :..:.::...|..::|..|.....:.::|||||.|.||....:.|..  ||..||.:|...:|..
pombe   237 MYFRLENSDEYDHLLKVYSGQTSFSLEEIEKDLGRSLPEYPAYQNEE--GINALRNVLVAFSWKN 299

  Fly   246 PDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLS 310
            .::||||...::.|.||:...||..|::|..|.||.:| .|||.|:.|...||:|..:|:...:.
pombe   300 QEVGYCQAMNIVAAALLIHCTEEQTFFLMHKICEDYIP-GYYSKTMYGTLIDQQVYESLVQRSMP 363

  Fly   311 SVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQD-L 374
            ::.......||:||:|:|.|||:||...:.:....|:.|:||.||..||||:.:.:|...|.: :
pombe   364 NLHAHFVSKDIQLSIISLPWFLSLFLCTMPLPYAFRLLDFFFLEGPRVLFQIGMAILYDNEAEIM 428

  Fly   375 KHLENSAQI------FNSLSDIP---------GEVTDVEVLFRQALEVGGSLSQTVIDTHRRRHL 424
            |..|::..|      |:||.|..         ..:|..::|...|.:....::.::|:..|::|.
pombe   429 KATEDTMLISILKNYFSSLGDKAYKDATDKRVASITKFQLLLVTAFKKFSHITHSLIEDERKKHY 493

  Fly   425 AYLMADQGHQIGNPEAAPNLPKQQLARRQVRKSKSILEAFLFRGDGNEGDQLKNKNIRQTEILVD 489
                          |...|..:....|.|:|..::.  ..|.|.|      |.|...|..|:|
pombe   494 --------------EGVMNSIESFAKRTQIRSLQNY--GTLTRTD------LSNIYDRYHEVL-- 534

  Fly   490 LREAILKVGRHFITIEPKLAGHIQLTANYSTESHAKDHENFINVARTRKRRAKAL---------- 544
                   ..:|.:.:            ..||::..:..|..|.:|...: .||.|
pombe   535 -------SSKHRVGL------------GSSTDTRLEFDEFCIFLAGVTE-WAKGLDAAAINNSSS 579

  Fly   545 ---HDFERHDDDELGFRRNDIITIISQKDEHCWVGELNGLRGWFPAKFVELLDERS---KLYTSA 603
               |.|.|.|....|        .:|.:|....:.||         ||.:::...|   :||...
pombe   580 FLRHLFLRFDKSMTG--------SLSLQDLVSGIAEL---------KFRDVMRNISFIFELYDFN 627

  Fly   604 GDDAISETVTDLVRGTLAPAIKAFLEHGMKRPTFLGGPIHPWLYIEEAATREVEKDFESVYSRLV 668
            ||..:.:  .|:::     ..:|.|                ||      ||.:..::.|..|
pombe   628 GDGFMDK--PDVLK-----VSEAIL----------------WL------TRFMGDEYLSAVS--- 660

  Fly   669 LCKTYRLDEDGKVLTPEELLYRCVQAINQTHDDAH----------------------AQMDVKL- 710
                             |.:.||....::...|.|                      |..|:|:
pombe   661 -----------------EFIQRCFHFADEASPDGHSDTLIDISDHMSSTGSENRSVGANSDIKVS 708

  Fly   711 -----RSLICLGLNEQVLHLWLE---VLCACQE 735
                 ..::.:||.||:....|.   ||...||
pombe   709 LPTFRMVVLSIGLLEQLFSGGLADSIVLAPVQE 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	73/214 (34%)
		SH3_SGSM3	540..592	CDD:212747	14/64 (22%)
		RUN	619..773	CDD:280855	25/148 (17%)
SPBC215.01	NP_596678.2	COG5210	1..476	CDD:227535	116/436 (27%)
		TBC	222..428	CDD:214540	71/208 (34%)
		EFh	581..639	CDD:298682	17/76 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840