DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and gyp3

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_587829.1	Gene:	gyp3 / 2539298	PomBaseID:	SPCC4G3.09c	Length:	635	Species:	Schizosaccharomyces pombe

Alignment Length:	501	Identity:	118/501 - (23%)
Similarity:	194/501 - (38%)	Gaps:	99/501 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ELPP-----MMEELSVADGL--RPNPGGPFSALTASMWPQEILAKLGGGAELASGPNDQPEYRFD 93
            |:||     ...|||..:..  .......|||:||:....|..::     :.:|..:....::.:
pombe   143 EIPPTDFLSTSTELSKRESCLSTETSSSKFSAVTAATITNETQSE-----KRSSQTDPSLPFKTN 202

  Fly    94 EFGFRVEEEDGP----------------------EQSSNKLLSIP-----------FVEDAQQRL 125
            .....|..|:||                      .:.:|:..::.           ::|..:||
pombe   203 SLNCDVTYEEGPLTKKLRGPKKYKPSHSSWDIYGFKKANQFYTVDQYNTWYGPYSRYLERREQR- 266

  Fly   126 QWIAHLEFSHNKEAAELSWEHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETS 190
             |...|:    :...:...:...:...|:.|.:..:|:|||...|...|...||.....|::...
pombe   267 -WKLFLQ----ENGIDYIHQSPSIFPSRSAKTQRFIRKGIPPEYRGNAWFYYSGGYELLQRNPKL 326

  Fly   191 YHDIVKASSNDQLMTSKQIEKDLLRILPTNACF------------------SNPNGTGIPRLRRI 237
            |..:.:.:...:...|..||:||.|..|.|..|                  ..|:...|.:|||:
pombe   327 YETLWRCACIKKPSDSDLIERDLYRTFPDNVHFRHKSKHSRNSSDASEHSSEEPDVPMISKLRRV 391

  Fly   238 LRGIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMH 302
            |...|...|:.||||....:....||||.||.||||:.......|| ..:.:.|.|...||.|:
pombe   392 LMTFATYLPENGYCQSLNFLAGFFLLFMSEEKAFWMLVITCRKYLP-KMHDANLEGANIDQSVL- 454

  Fly   303 TLIANYLSSVDESLRK--------------HDI-----ELSLITLHWFLTLFANVVHMKILVRIW 348
                  ::||.|||..              :||     .::|:|..||::.|..::..:..:|:|
pombe   455 ------MASVRESLPAVWSRISLNFDGIPVNDIVAKLPPITLVTAAWFMSAFVGILPTETALRVW 513

  Fly   349 DWFFYEGSIVLFQLTLGMLKVKEQDLKHLENSAQIFNSLSDIPGEVTDVEVLFRQALEVGGSLSQ 413
            |.||||||.|||...|.:|::.|.|:|......::|..:.|:|..:.|...............:.
pombe   514 DCFFYEGSKVLFMTALCILRLGEDDIKSKSEQTEVFQVIQDLPKSLLDANAFLSLCFRRNFRRTP 578

  Fly   414 TVIDTHRRRHLAYLMADQGHQIGNPEAAPNLPKQQLARRQVRKSKS 459
            :..|..|||.   .:|.:.:...:.....:..|..|:|...|.|||
pombe   579 SQKDIERRRE---KVAKKRNSSASKLEMSDSSKHHLSRSSSRFSKS 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	76/250 (30%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
gyp3	NP_587829.1	COG5210	22..576	CDD:227535	106/451 (24%)
gyp3	NP_587829.1	TBC	297..540	CDD:214540	76/250 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840