DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and Tbc1d8b

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_001074968.1	Gene:	Tbc1d8b / 245638	MGIID:	1918101	Length:	1114	Species:	Mus musculus

Alignment Length:	704	Identity:	168/704 - (23%)
Similarity:	298/704 - (42%)	Gaps:	139/704 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 QEILAKLGGGAELASGPND------------QPEYRFDEFGFRVEEEDGPEQSSNKLLSI--PFV 118
            ::::|||......||..:|            .|...|:|......:|.....::..|:::  |
Mouse   378 EQLVAKLRLKCRAASTQDDVSTEVAVSSDSTGPSENFEEQPLTCPKECSKTVNTEALMTVFHP-- 440

  Fly   119 EDAQQRLQWIAHLEFSHNKE-AAELSWEHV------DVMLPRTEKLRNMVRQGIPHTLRAQMWMR 176
                   |.:.:|:....|| ..|.||..:      .|.:.||:|.|::|.:|||.|||.::||.
Mouse   441 -------QNLENLDSKMLKEKMKEQSWNILFSECGRGVSMFRTKKTRDLVVRGIPETLRGELWML 498

  Fly   177 LSGALAKKQKSETSYHDIVKASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGI 241
            .|||:.....:...|.::|:.|.....:.:::||:||.|.||.:..|.  :.|||..|||:|...
Mouse   499 FSGAVNDMATNPGYYAEVVEQSLGTSNLATEEIERDLRRSLPEHPAFQ--SDTGISALRRVLTAY 561

  Fly   242 AWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIA 306
            |:..|.|||||...::.:.|||:.:||.|||::..:.|.:|| .|::..::|...||.|...||.
Mouse   562 AYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLP-DYFNRRIIGALVDQAVFEELIR 625

  Fly   307 NYLSSVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKE 371
            ::|..:.:.:..... .|.::|.||||||.:|:.::..|.:.|.|||:|...:.||.|.:|....
Mouse   626 DHLPQLTDHMTDMTF-FSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNL 689

  Fly   372 QDLKHLENSAQ-----------IFNSLSDIPGEV---------------TDVEVLFRQALEVGGS 410
            ..|...::.|:           :.|..|.:|..|               .|:..|.:::.|..||
Mouse   690 DKLLTCKDDAEAVTALNRFFDNVINKDSPLPSNVQQGSNISNEKSDHTKVDITDLIKESNEKYGS 754

  Fly   411 LSQTVIDTHRRRHLAYLMADQGHQIGNPEAAPNLPKQQLAR---RQVRKSKSILEAFLFRGDGNE 472
            :....|.:.|.|:..|::          :......||.:.|   :.|:.|...|:
Mouse   755 IRYEDIHSMRCRNRLYVI----------QTLEETTKQNVLRVVSQDVKMSLQELD---------- 799

  Fly   473 GDQLKNKNIRQTEILVDLREAILKVGRHFITIEPKLAGHIQLTANYSTESHAKDHENFINV---- 533
                        |:.|..::.:. :..::....|.|..| ..:..| .|.:..|.:.|..:
Mouse   800 ------------ELYVIFKKELF-ISCYWYLSCPGLKHH-DPSLPY-LEQYQIDCQQFRVLYHLL 849

  Fly   534 ---ARTRKRRAKALHDFERHDDDE---LGFRR----NDIITIISQKDEHCWVGELNGLRGWFPAK 588
               |.:..|.:.||..|...|::.   :.|:.    .||:...|..|:...:.:|:     .|..
Mouse   850 SPWAHSANRDSLALWTFRLLDENSDCLINFKEFSSAIDIMYNGSFTDKLKLLFKLH-----IPPA 909

  Fly   589 FVELLDERSKLYTSAGDDAISETVTDLVRGTLA-PAIKAFLEHGMKRPTFLGGPIHPWLYI---- 648
            :.|::.:.|    |.||:..:|.:....:..:: ||.:...|.|...|....|.|....|:
Mouse   910 YTEVMSKTS----SKGDELSTEELLYFSQLQVSKPADEKETESGRNSPEKGKGKIDIQAYLSQWQ 970

  Fly   649 -----EEAATREVEKDFESVYSRLVLCKT-YRL-DEDGKVLTPEELLYRCVQAI 695
                 :|...:::.:..:|.:  :...|| |.| .||.:    ||.||:.:..:
Mouse   971 DELLKKEETIKDLPRMNQSQF--IQFSKTLYNLFHEDPE----EESLYQAIAIV 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	75/213 (35%)
		SH3_SGSM3	540..592	CDD:212747	11/58 (19%)
		RUN	619..773	CDD:280855	20/89 (22%)
Tbc1d8b	NP_001074968.1	PH-GRAM1_TBC1D8B	156..254	CDD:275419
		PH-GRAM2_TBC1D8B	296..388	CDD:270159	3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..420		3/20 (15%)
		TBC	485..693	CDD:214540	74/211 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	938..957		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1032..1061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840