DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12241 and RABGAP1

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_036329.3	Gene:	RABGAP1 / 23637	HGNCID:	17155	Length:	1069	Species:	Homo sapiens

Alignment Length:	624	Identity:	141/624 - (22%)
Similarity:	222/624 - (35%)	Gaps:	193/624 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 TASMWPQEILAKLGGGAELASGPNDQPEYRFDEFGFRVEEEDGPEQSSNKLLSIPFVEDAQQRLQ 126
            |||  |...|.:.|..:.:...|   ||   |:     ||||..|         |.:..:.
Human   489 TAS--PSVRLPQSGSQSSVIPSP---PE---DD-----EEEDNDE---------PLLSGSG---- 527

  Fly   127 WIAHLEFSHNKEAAE---------LSWEHVDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALA 182
                   ..:||.||         ||..|:::.: |.::|.::||.|:|..||.::|..|:|...
Human   528 -------DVSKECAEKILETWGELLSKWHLNLNV-RPKQLSSLVRNGVPEALRGEVWQLLAGCHN 584

  Fly   183 KKQKSETSYHDIVKASSNDQLMTSKQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPD 247
            .....|.....|.|.|..|..:|     :|:.|..|.:..|.:..|.|...|.:|.:..:....:
Human   585 NDHLVEKYRILITKESPQDSAIT-----RDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEE 644

  Fly   248 IGYCQGTGVIVACLLLFMEEENAFWMMATIVEDL------------LPASYYSSTLLGIQADQRV 300
            ||||||...:.|.|||.|.||.||.::..|:.|.            |...:|..        :|:
Human   645 IGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQL--------ERL 701

  Fly   301 MHTLIAN-YLSSVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTL 364
            |...|.: |...:|.||..|     :....||||||.....:.::..|.|....||..|:|.:.|
Human   702 MQEYIPDLYNHFLDISLEAH-----MYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVAL 761

  Fly   365 GMLKVKEQDLKHLENSAQIFNSLSDIPGEVTDVEVLF----------RQALEVGGS--LSQTVID 417
            |:||..:.||           .|:|..|.:....|..          ::.:|:..:  :||..:.
Human   762 GLLKTSKDDL-----------LLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLK 815

  Fly   418 THRRRHLAYLMADQGHQIGNP-------------------------------------------- 438
            .:.:.:  :.|.:|..|..:|
Human   816 KYEKEY--HTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDNAE 878

  Fly   439 EAAPNLPKQQL------------ARRQVRKSKSILEAFLFRGDGNEGDQLKNKNI---------- 481
            |.|..|.|:.|            .||...:|..:.|......|..|.:..||.:|
Human   879 EKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIGDYKQICSQ 943

  Fly   482 -------RQTEILVDLREAILKVG-----RHFITIEPKLAGHIQLTANYSTESHAKDHENFIN-- 532
                   :||...|::.:...||.     |.|...|.::.| |..|.....|...::.|...|
Human   944 LSERLEKQQTANKVEIEKIRQKVDDCERCREFFNKEGRVKG-ISSTKEVLDEDTDEEKETLKNQL 1007

  Fly   533 ------VARTRKRRAKA---LHDFERHDDDELGFRRNDI 562
                  :|:|:.:..:|   :.|.|.|    ||...|::
Human  1008 REMELELAQTKLQLVEAECKIQDLEHH----LGLALNEV 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	67/226 (30%)
		SH3_SGSM3	540..592	CDD:212747	7/26 (27%)
		RUN	619..773	CDD:280855
RABGAP1	NP_036329.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..79
		PTB_Rab6GAP	145..273	CDD:269922
		DUF3694	307..437	CDD:403614
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..527		16/59 (27%)
		TBC	563..772	CDD:214540	68/237 (29%)
		Smc	<823..>1047	CDD:224117	41/225 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810