DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12241 and Tbc1d17

DIOPT Version :9

Sequence 1:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster
Sequence 2:	NP_001036120.1	Gene:	Tbc1d17 / 233204	MGIID:	2449973	Length:	645	Species:	Mus musculus

Alignment Length:	404	Identity:	90/404 - (22%)
Similarity:	149/404 - (36%)	Gaps:	113/404 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LRPNPGGPFSALTASMWPQEILAKLGGGAELASGPNDQPEYRFD-----EFGFR--------VEE 101
            |:|:|.|..|                  ..|...|:|:||..|:     |.|.|        |.|
Mouse   237 LQPHPEGASS------------------PNLPPLPDDEPEPGFEVISCVELGQRPTVERAPPVTE 283

  Fly   102 ED-----GPEQSSNKLLSIPFVED---------AQQRLQWIAHLEFSHNKEAAELSWEHVDVMLP 152
            |:     |||   .:|.::|.:::         ..:|..|...|.:        ||||      .
Mouse   284 EEWNRYVGPE---GRLQNVPELKNRIFSGGLSPGLRREAWKFLLGY--------LSWE------S 331

  Fly   153 RTEKLRNMVRQGIPHTLRAQM-WMRLSGALAKKQKSETSYHDIVKASSNDQLMTSKQIEKDLLRI 216
            ..|:.:..||:......|.:: |..:|....::......|..:              ||:|:.|.
Mouse   332 SAEEHKAHVRKKTDEYFRMKLQWKSVSAEQERRNSLLHGYRSL--------------IERDVSRT 382

  Fly   217 LPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEE-NAFWMMATIVED 280
            ..||..:..|...|:..|..||........|:||.||...:::.:|..::.| :|||.....:|
Mouse   383 DRTNKFYEGPENPGLSLLHDILLTYCMYHFDLGYVQGMSDLLSPILFVVQNEVDAFWCFCGFME- 446

  Fly   281 LLPASY-YSSTLLGIQADQ-----RVMHTLIANYLSSVDESLRKHDIELSL-ITLHWFLTLFANV 338
            |:..:: .|...:..|..|     ||:...:.::|.|.|..        || ....|.|..|...
Mouse   447 LVHGNFEESQETMKRQLGQLLLLLRVLDQPLCDFLDSQDSG--------SLCFCFRWLLIWFKRE 503

  Fly   339 VHMKILVRIWD--WFFYEGSIVLFQLTLGMLKVKEQD------------LKHLENSAQIFNSLSD 389
            .....::|:|:  |....|..:...:...:|.: |:|            |||: |...:..|:.|
Mouse   504 FPFPDVLRLWEVLWTGLPGPNLHLLVACAILDM-ERDTLMLSGFGSNEILKHI-NELTMKLSVED 566

  Fly   390 IPGEVTDVEVLFRQ 403
            :   :|..|.|:||
Mouse   567 V---LTRAEALYRQ 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12241	NP_650432.1	TBC	161..375	CDD:214540	49/236 (21%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
Tbc1d17	NP_001036120.1	DUF3548	3..217	CDD:192931
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..85
		Required for interaction with OPTN. /evidence=ECO:0000250	217..309		22/92 (24%)
		TBC	307..542	CDD:214540	57/272 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..645
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900